PASSAG聚合物凝胶剂量计在电子束放射治疗中的磁共振成像剂量学特性。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Tiancheng Zhang, Yasir Q Almajidi, Sameer A Awad, Firas Rahi Alhachami, Maher Abdulfadhil Gatea, Wesam R Kadhum
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引用次数: 0

摘要

背景:光子束能量、电子束能量和剂量率等物理因素可能影响聚合物凝胶剂量计的剂量测定性能。对PASSAG凝胶剂量计的光子束流能量和剂量率依赖性进行了评价。目的:研究优化后的PASSAG凝胶样品在不同电子束能量下的剂量学特性。方法:首先制备优化后的PASSAG凝胶样品,并在不同电子能(5、7、10和12 MeV)下辐照。在0 ~ 10 Gy的剂量范围、15 ~ 22℃的室温扫描范围和1 ~ 30天的辐照后时间范围内,通过磁共振成像技术分析凝胶样品的响应(R2)和灵敏度。结果:凝胶样品的r2剂量响应和灵敏度在评价的电子束能量下没有变化(差异小于5%)。此外,凝胶样品在不同电子束能量照射下的剂量分辨范围为11 ~ 38 cGy。此外,研究结果表明,凝胶样品的r2剂量响应和灵敏度依赖于电子束能量随扫描室温和辐照后时间的不同而变化。结论:优化后的PASSAG凝胶样品的剂量学评价为该剂量计在电子束放疗中的应用提供了有前景的数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dosimetric properties of PASSAG polymer gel dosimeter in electron beam radiotherapy using magnetic resonance imaging.

Background: Several physical factors such as photon beam energy, electron beam energy, and dose rate may affect the dosimetric properties of polymer gel dosimeters. The photon beam energy and dose rate dependence of PASSAG gel dosimeter were previously evaluated.

Objective: This study aims to assess the dosimetric properties of the optimized PASSAG gel samples in various electron beam energies.

Methods: The optimized PASSAG gel samples are first fabricated and irradiated to various electron energies (5, 7, 10 and 12 MeV). Then, the response (R2) and sensitivity of gel samples are analyzed by magnetic resonance imaging technique at a dose range of 0 to 10 Gy, scanning room temperature range of 15 to 22 °C, and post-irradiation time range of 1 to 30 days.

Results: The R2-dose response and sensitivity of gel samples do not change under the evaluated electron beam energies (the differences are less than 5%). Furthermore, a dose resolution range of 11 to 38 cGy is obtained for the gel samples irradiated to different electron beam energies. Moreover, the findings show that the R2-dose response and sensitivity dependence of gel samples on electron beam energy varies over different scanning room temperatures and post-irradiation times.

Conclusion: The dosimetric assessment of the optimized PASSAG gel samples provides the promising data for this dosimeter during electron beam radiotherapy.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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