AGEs阻断剂™(枸杞、无花果和韩国薄荷混合提取物)抑制无毛小鼠由链脲佐菌素诱导的糖基化引起的皮肤老化。

IF 1.6 Q3 FOOD SCIENCE & TECHNOLOGY
Jin Hee Yoo, Je Sung Lee, Ji Hwan Jang, Jae In Jung, Eun Ji Kim, Su-Young Choi
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引用次数: 0

摘要

糖基化是皮肤老化的原因之一。在糖基化皮肤老化小鼠模型中,研究了枸杞、无花果和薄荷混合提取物的AGEs阻断剂(AB)对皮肤的影响及其作用机制。本研究旨在通过测量晚期糖基化终产物(AGEs)和各种皮肤参数,包括胶原蛋白,来证明链脲佐菌素的抗糖基化作用,从而改善皮肤衰老;基质金属蛋白酶;炎性细胞因子;氧化酶活性;和皮肤的皱纹,弹性和水合作用。本研究发现AB可改善皮肤皱纹、弹性和水合作用。特别是口服AB可抑制血液和皮肤组织中的AGEs、AGEs受体和羧甲基赖氨酸。此外,AB还能提高抗氧化酶活性,降低炎症因子,抑制MMP-9表达,增加胶原蛋白和透明质酸含量,最终抑制皮肤皱纹,增加皮肤弹性和水合性。因此,AB可以通过其抗糖化作用抑制皮肤老化,因此被认为是一种很好的护肤产品成分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

AGEs Blocker™ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice.

AGEs Blocker™ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice.

AGEs Blocker™ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice.

AGEs Blocker™ (Goji Berry, Fig, and Korean Mint Mixed Extract) Inhibits Skin Aging Caused by Streptozotocin-Induced Glycation in Hairless Mice.

Glycation is a cause of skin aging. This study investigated in a glycation-induced skin aging mouse model the effects on skin and mechanism of action of AGEs Blocker™ (AB), which contains goji berry, fig, and Korean mint mixed extract. This study sought to demonstrate the antiglycation effect of streptozotocin, thereby improving skin aging, by measuring advanced glycation end products (AGEs) and various skin parameters, including collagen; matrix metalloproteinases (MMPs); inflammatory cytokines; activities of oxidative enzymes; and skin wrinkles, elasticity, and hydration. This study found that skin wrinkles, elasticity, and hydration improved with AB. Particularly, the oral administration of AB suppressed AGEs, receptors of AGEs, and carboxymethyl lysine in blood and skin tissue. In addition, AB increased the activities of antioxidative enzymes, reduced inflammatory cytokines, suppressed MMP-9 expression, and increased the contents of collagen and hyaluronic acid, ultimately suppressing skin wrinkles and increasing skin elasticity and hydration. Therefore, AB can inhibit skin aging through its antiglycation effect and is thus considered a good ingredient for skin care products.

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来源期刊
Preventive Nutrition and Food Science
Preventive Nutrition and Food Science Agricultural and Biological Sciences-Food Science
CiteScore
3.40
自引率
0.00%
发文量
35
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