复发性食管癌第二疗程放疗的 Meta 分析1。

IF 1.7 3区 医学 Q3 INSTRUMENTS & INSTRUMENTATION
Pengcheng Xu, Yongsheng Liu, Shen Wu, Dong Cheng, Zhanfeng Sun
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引用次数: 0

摘要

背景:如何通过第二疗程单独放疗和联合化疗提高治疗复发性食管癌的疗效并减少副作用一直是研究的热点:如何通过第二疗程单独放疗和联合化疗提高治疗复发性食管癌的疗效并减少副作用一直受到广泛关注:本综述旨在系统评估单独应用第二疗程前向放疗和联合化疗治疗复发性食管癌的疗效和副作用:首先,从PubMed、CNKI和万方数据库中检索相关研究论文。然后,使用 Redman 5.3 软件计算相对危险度和 95% 的置信区间,以评价单次放疗联合或不联合单次/多次化疗治疗复发性食管癌的疗效和不良反应。然后,应用荟萃数据分析研究单纯放疗和再放疗加化疗治疗食管癌首次放疗后复发的疗效和副作用:结果:检索到15篇论文,共纳入956名患者。其中,476 例患者接受放疗联合单药/多药化疗(观察组),其他患者仅接受放疗(对照组)。数据分析结果显示,观察组患者放疗引起肺损伤和骨髓抑制的发生率较高。亚组分析还显示,第二疗程放疗联合单药化疗的患者有效率或一年总生存率更高:荟萃分析结果表明,第二疗程放疗联合单药化疗在治疗复发性食管癌方面具有优势,且副作用可控。然而,由于数据不足,无法进一步进行亚组分析,比较恢复性放疗与单药和多药联合化疗的副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Meta analysis of the second course of radiotherapy for recurrent esophageal cancer1.

Background: How to improve efficacy and reduce side effects in treating recurrent esophageal cancer by applying the second course of radiotherapy alone and its combination with chemotherapy has been attracting broad research interest.

Objective: This review paper aims to systematically evaluate efficacy and side effects of applying the second course of anterograde radiotherapy alone and its combination with chemotherapy in treating recurrent esophageal cancer.

Methods: First, the relevant research papers are retrieved from PubMed, CNKI and Wanfang databases. Next, Redman 5.3 software is used to calculate the relative risk and 95% confidence interval to evaluate the efficacy and adverse reactions of applying the single-stage radiotherapy with and without combining single/multi dose chemotherapy to treat recurrent esophageal cancer. Then, a meta data analysis is applied to examine the effectiveness and side effects of radiation alone and re-course radiotherapy plus chemotherapy in treating esophageal cancer recurrence after the first radiotherapy.

Results: Fifteen papers are retrieved, which included 956 patients. Among them, 476 patients received radiotherapy combined with single drug/multi drug chemotherapy (observation) and others received only radiotherapy (control). Data analysis results show that the incidence of radiation induced lung injury and bone marrow suppression is high in the observation group. Subgroup analysis also shows the higher effective rate or one-year overall survival rate of patients treated with the second course radiotherapy combined with single drug chemotherapy.

Conclusion: The meta-analysis result demonstrates that combining the second course of radiotherapy with single-drug chemotherapy has advantages in treating recurrent esophageal cancer with the manageable side effects. However, due to insufficient data, it is not possible to conduct the further subgroup analysis comparing the side effects of restorative radiation with the combined chemotherapy using between a single drug and multiple drugs.

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来源期刊
CiteScore
4.90
自引率
23.30%
发文量
150
审稿时长
3 months
期刊介绍: Research areas within the scope of the journal include: Interaction of x-rays with matter: x-ray phenomena, biological effects of radiation, radiation safety and optical constants X-ray sources: x-rays from synchrotrons, x-ray lasers, plasmas, and other sources, conventional or unconventional Optical elements: grazing incidence optics, multilayer mirrors, zone plates, gratings, other diffraction optics Optical instruments: interferometers, spectrometers, microscopes, telescopes, microprobes
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