二甲硫醚(农药)。

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引用次数: 0

摘要

日本食品安全委员会(FSCJ)根据多项研究结果,对磺胺类除草剂二磺胺除草剂(CAS No. 1215111-77-5)进行了风险评估。评估中使用的数据包括植物(水稻)的毒性、作物中的残留物、动物(大鼠)的毒性、亚急性毒性(大鼠、小鼠和狗)、慢性毒性(狗)、慢性毒性/致癌性(大鼠)、致癌性(小鼠)、急性神经毒性(大鼠)、亚急性神经毒性(大鼠)、两代生殖毒性(大鼠)、发育毒性(大鼠和家兔)和遗传毒性。从这些试验结果中观察到,二硫代锌的主要不良反应是在体重(所有试验结果均抑制体重增加)、肾脏(大鼠体重增加)和膀胱(小鼠和狗的尿路上皮增生)方面。未观察到致癌性、神经毒性和遗传毒性。未发现对生育能力有明显影响。在为期两年的大鼠慢性毒性/致癌性联合研究中,所有研究中获得的最低无观察到不良反应水平(NOAEL)为每天0.39 mg/kg体重。在此基础上,FSCJ在对NOAEL应用100的安全系数后,规定了每日可接受摄入量(ADI)为0.0039毫克/千克体重/天。在家兔的发育毒性研究中,单次口服二硫肼后潜在不良反应的最低NOAEL为每天15 mg/kg bw。因此,FSCJ在对怀孕或可能怀孕的妇女应用100的安全系数后规定了0.15 mg/kg bw的急性参考剂量(ARfD)。对于一般人群,在应用安全系数为300后,ARfD为0.41 mg/kg bw(在大鼠急性神经毒性研究中,应用LOAEL为125 mg/kg bw的附加系数为3)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dimesulfazet (Pesticides).

Food Safety Commission of Japan (FSCJ) conducted a risk assessment of a sulfonanilide herbicide, dimesulfazet (CAS No. 1215111-77-5), based on results from various studies. The data used in the assessment include the fate in plants (paddy rice), residues in crops, fate in animals (rats), subacute toxicity (rats, mice and dogs), chronic toxicity (dogs), combined chronic toxicity/carcinogenicity (rats), carcinogenicity (mice), acute neurotoxicity (rats), subacute neurotoxicity (rats), two-generation reproductive toxicity (rats), developmental toxicity (rats and rabbits), and genotoxicity. The major adverse effects of dimesulfazet from those test results were observed in body weight (suppressed body weight gain in all test results), kidneys (increased weight in rats) and urinary bladder (urothelial hyperplasia in mice and dogs). None of carcinogenicity, neurotoxicity and genotoxicity were observed. No obvious effects on fertility were detected. The lowest no-observed-adverse-effect level (NOAEL) obtained from all the studies was 0.39 mg/kg bw per day in two-year combined chronic toxicity/carcinogenicity study in rats. On the basis of this value, FSCJ specified an acceptable daily intake (ADI) of 0.0039 mg/kg bw per day after applying a safety factor of 100 to the NOAEL. The lowest NOAEL for potential adverse effects after a single oral administration of dimesulfazet was 15 mg/kg bw per day in the developmental toxicity study in rabbits. FSCJ thus specified an acute reference dose (ARfD) of 0.15 mg/kg bw after applying a safety factor of 100 for women who are pregnant or might be pregnant. For the general population, an ARfD of 0.41 mg/kg bw after applying a safety factor of 300 (additional factor 3 by applying LOAEL of 125 mg/kg bw resulted from acute neurotoxicity study in rats).

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