视网膜的内稳态可塑性

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY
Michael J. Fitzpatrick , Daniel Kerschensteiner
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引用次数: 5

摘要

视觉始于视网膜,其复杂的神经回路从进入我们眼睛的光线中提取环境的显著特征。视网膜神经退行性疾病(如遗传性视网膜变性、年龄相关性黄斑变性和青光眼)损害视力并导致全球越来越多的人失明。越来越多的证据表明,稳态可塑性(即神经系统稳定其功能的驱动力)原则上可以在面临包括神经退行性变在内的重大扰动时保持视网膜功能。在这里,我们回顾了在发育、感官体验和疾病过程中触发视网膜稳态可塑性的情况和事件。我们讨论了协同补偿的各种机制,以及稳态视网膜可塑性稳定的设定点和结果。最后,我们总结了释放稳态可塑性治疗潜力的机遇和挑战。稳态可塑性是理解视网膜发育和功能的基础,可能是保护和恢复视力的重要工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Homeostatic plasticity in the retina

Vision begins in the retina, whose intricate neural circuits extract salient features of the environment from the light entering our eyes. Neurodegenerative diseases of the retina (e.g., inherited retinal degenerations, age-related macular degeneration, and glaucoma) impair vision and cause blindness in a growing number of people worldwide. Increasing evidence indicates that homeostatic plasticity (i.e., the drive of a neural system to stabilize its function) can, in principle, preserve retinal function in the face of major perturbations, including neurodegeneration. Here, we review the circumstances and events that trigger homeostatic plasticity in the retina during development, sensory experience, and disease. We discuss the diverse mechanisms that cooperate to compensate and the set points and outcomes that homeostatic retinal plasticity stabilizes. Finally, we summarize the opportunities and challenges for unlocking the therapeutic potential of homeostatic plasticity. Homeostatic plasticity is fundamental to understanding retinal development and function and could be an important tool in the fight to preserve and restore vision.

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来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
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