局部联合余甘子。辛伐他汀通过促进血管生成和减少中性粒细胞浸润来促进糖尿病小鼠的伤口愈合。

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Ting-Ting Liao, Supakanda Sukpat, Chaisak Chansriniyom, Suthiluk Patumraj
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引用次数: 2

摘要

本研究旨在探讨复方余甘子的抗氧化作用。(PE)和辛伐他汀(SIM)对雄性BALB/C小鼠糖尿病创面的影响。对照组和糖尿病组均行双侧全层创面切除(45 mg/kg链脲佐菌素,每日腹腔注射,连续5 d)。糖尿病小鼠每天给予4种不同类型的乳膏:载药[糖尿病(DM) +载药组]、100% PE (DM + PE组)、5% SIM (DM + SIM组)和100% PE + 5% SIM (DM +联合组),治疗4、7和14 d。随后测定组织丙二醛(MDA)和IL-6蛋白水平,浸润中性粒细胞数量,伤口愈合百分比(%WC),毛细血管密度(%CV)和再上皮化百分比(%RE)。结果表明,与DM + Vehicle组相比,DM + Combination组在第7天和第14天的%CV和%WC均显著升高。与DM + Vehicle组相比,DM + Combination组第14天组织MDA含量、第4、7天浸润中性粒细胞数量显著减少。此外,5组患者在第7天的%CV与%WC之间呈显著正相关(r=0.736;P = 0.0003)。这些结果表明,局部应用PE和SIM可通过上调糖尿病创面血管生成和减少中性粒细胞浸润来促进创面愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Topical combined <i>Phyllanthus emblica</i> Linn. and simvastatin improves wound healing in diabetic mice by enhancing angiogenesis and reducing neutrophil infiltration.

Topical combined <i>Phyllanthus emblica</i> Linn. and simvastatin improves wound healing in diabetic mice by enhancing angiogenesis and reducing neutrophil infiltration.

Topical combined <i>Phyllanthus emblica</i> Linn. and simvastatin improves wound healing in diabetic mice by enhancing angiogenesis and reducing neutrophil infiltration.

Topical combined Phyllanthus emblica Linn. and simvastatin improves wound healing in diabetic mice by enhancing angiogenesis and reducing neutrophil infiltration.

The present study aimed to investigate the effects of combined Phyllanthus emblica Linn. (PE) and simvastatin (SIM) on diabetic wounds in male BALB/C mice. Bilateral full thickness wound excisions were performed in the control and diabetic groups (45 mg/kg streptozotocin, intraperitoneally injected daily for 5 days). The diabetic mice received daily treatment with four different types of cream: Vehicle [diabetes mellitus (DM) + Vehicle group], 100% PE (DM + PE group), 5% SIM (DM + SIM group) and combined 100% PE + 5% SIM (DM + Combination group) for 4, 7 and 14 days. The tissue malondialdehyde (MDA) and IL-6 protein levels, the number of infiltrated neutrophils, and the percentages of wound closure (%WC), capillary vascularity (%CV) and re-epithelialization (%RE) were subsequently measured. The results indicated that in the DM + Combination group, %CV and %WC were significantly increased when compared with the DM + Vehicle group on days 7 and 14. The tissue MDA content on day 14, and the number of infiltrated neutrophils on days 4 and 7 were significantly reduced in the DM + Combination group compared with those in the DM + Vehicle group. Furthermore, a strong positive correlation was revealed between %CV and %WC in the five groups on day 7 (r=0.736; P=0.0003). These findings indicated that topical application of combined PE and SIM could enhance wound healing by upregulating angiogenesis and reducing neutrophil infiltration in mice with diabetic wounds.

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来源期刊
Biomedical reports
Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.10
自引率
0.00%
发文量
86
期刊介绍: Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.
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