Martine Mauget-Faÿsse, Georges Sukkarieh, Hajar Jebrane, Justine Lafolie, Anne Sophie Alonso, Elsa Laumonier, Sabine Derrien, Veronique Le Guern, Francine Behar-Cohen, Sophie Thevenin, Emmanuel Augé, Jessica Guillaume, Vivien Vasseur, Nathalie Costedoat-Chalumean
{"title":"“En Face”光谱域光学相干断层扫描与多焦视网膜电图在羟氯喹视网膜病变筛查中的应用。","authors":"Martine Mauget-Faÿsse, Georges Sukkarieh, Hajar Jebrane, Justine Lafolie, Anne Sophie Alonso, Elsa Laumonier, Sabine Derrien, Veronique Le Guern, Francine Behar-Cohen, Sophie Thevenin, Emmanuel Augé, Jessica Guillaume, Vivien Vasseur, Nathalie Costedoat-Chalumean","doi":"10.1159/000528146","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The performance of \"en face\" optical coherence tomography (OCT) in screening for chloroquine (CQ) or hydroxychloroquine (HCQ) retinopathy has not been largely explored. The aim of this study was to determine the concordance of \"en face\" OCT with multifocal electroretinography (mfERG) in screening for CQ/HCQ retinopathy.</p><p><strong>Methods: </strong>This is a prospective cohort study conducted at the Rothschild Foundation Hospital, Paris, between August 2016 and February 2021. Patients taking HCQ were followed up over 2 consecutive years and received an \"en face\" OCT and a mfERG on each visit.</p><p><strong>Results: </strong>A total of 91 patients (182 eyes) were analyzed. mfERG and \"en face\" OCT were concordant in 147 eyes (86.3%). Cohen's kappa coefficient for concordance between mfERG and \"en face\" OCT was considered weak with a value 0.61 (95% CI: 0.50-0.72). The sensitivity and specificity of \"en face\" OCT were 70% (95% CI: 59-79%) and 91% (95% CI: 83-96%), respectively, relatively to mfERG. Proportion of abnormal R2/R5 and R3/R5 ratios did not differ between patients with normal and abnormal \"en face\" OCT (p = 0.2).</p><p><strong>Discussion: </strong>\"En face\" OCT and mfERG have low concordance and cannot be used interchangeably as each investigation evaluates a different facet of CQ/HCQ retinopathy. \"En face\" OCT could be used as a complement in screening for CQ/HCQ retinal toxicity if the anomalies detected on \"en face\" OCT are confirmed by B-scan OCT sections.</p>","PeriodicalId":19595,"journal":{"name":"Ophthalmologica","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"\\\"En Face\\\" Spectral-Domain Optical Coherence Tomography versus Multifocal Electroretinogram in Hydroxychloroquine Retinopathy Screening.\",\"authors\":\"Martine Mauget-Faÿsse, Georges Sukkarieh, Hajar Jebrane, Justine Lafolie, Anne Sophie Alonso, Elsa Laumonier, Sabine Derrien, Veronique Le Guern, Francine Behar-Cohen, Sophie Thevenin, Emmanuel Augé, Jessica Guillaume, Vivien Vasseur, Nathalie Costedoat-Chalumean\",\"doi\":\"10.1159/000528146\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The performance of \\\"en face\\\" optical coherence tomography (OCT) in screening for chloroquine (CQ) or hydroxychloroquine (HCQ) retinopathy has not been largely explored. The aim of this study was to determine the concordance of \\\"en face\\\" OCT with multifocal electroretinography (mfERG) in screening for CQ/HCQ retinopathy.</p><p><strong>Methods: </strong>This is a prospective cohort study conducted at the Rothschild Foundation Hospital, Paris, between August 2016 and February 2021. Patients taking HCQ were followed up over 2 consecutive years and received an \\\"en face\\\" OCT and a mfERG on each visit.</p><p><strong>Results: </strong>A total of 91 patients (182 eyes) were analyzed. mfERG and \\\"en face\\\" OCT were concordant in 147 eyes (86.3%). Cohen's kappa coefficient for concordance between mfERG and \\\"en face\\\" OCT was considered weak with a value 0.61 (95% CI: 0.50-0.72). The sensitivity and specificity of \\\"en face\\\" OCT were 70% (95% CI: 59-79%) and 91% (95% CI: 83-96%), respectively, relatively to mfERG. Proportion of abnormal R2/R5 and R3/R5 ratios did not differ between patients with normal and abnormal \\\"en face\\\" OCT (p = 0.2).</p><p><strong>Discussion: </strong>\\\"En face\\\" OCT and mfERG have low concordance and cannot be used interchangeably as each investigation evaluates a different facet of CQ/HCQ retinopathy. \\\"En face\\\" OCT could be used as a complement in screening for CQ/HCQ retinal toxicity if the anomalies detected on \\\"en face\\\" OCT are confirmed by B-scan OCT sections.</p>\",\"PeriodicalId\":19595,\"journal\":{\"name\":\"Ophthalmologica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000528146\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000528146","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
"En Face" Spectral-Domain Optical Coherence Tomography versus Multifocal Electroretinogram in Hydroxychloroquine Retinopathy Screening.
Introduction: The performance of "en face" optical coherence tomography (OCT) in screening for chloroquine (CQ) or hydroxychloroquine (HCQ) retinopathy has not been largely explored. The aim of this study was to determine the concordance of "en face" OCT with multifocal electroretinography (mfERG) in screening for CQ/HCQ retinopathy.
Methods: This is a prospective cohort study conducted at the Rothschild Foundation Hospital, Paris, between August 2016 and February 2021. Patients taking HCQ were followed up over 2 consecutive years and received an "en face" OCT and a mfERG on each visit.
Results: A total of 91 patients (182 eyes) were analyzed. mfERG and "en face" OCT were concordant in 147 eyes (86.3%). Cohen's kappa coefficient for concordance between mfERG and "en face" OCT was considered weak with a value 0.61 (95% CI: 0.50-0.72). The sensitivity and specificity of "en face" OCT were 70% (95% CI: 59-79%) and 91% (95% CI: 83-96%), respectively, relatively to mfERG. Proportion of abnormal R2/R5 and R3/R5 ratios did not differ between patients with normal and abnormal "en face" OCT (p = 0.2).
Discussion: "En face" OCT and mfERG have low concordance and cannot be used interchangeably as each investigation evaluates a different facet of CQ/HCQ retinopathy. "En face" OCT could be used as a complement in screening for CQ/HCQ retinal toxicity if the anomalies detected on "en face" OCT are confirmed by B-scan OCT sections.
期刊介绍：
Published since 1899, ''Ophthalmologica'' has become a frequently cited guide to international work in clinical and experimental ophthalmology. It contains a selection of patient-oriented contributions covering the etiology of eye diseases, diagnostic techniques, and advances in medical and surgical treatment. Straightforward, factual reporting provides both interesting and useful reading. In addition to original papers, ''Ophthalmologica'' features regularly timely reviews in an effort to keep the reader well informed and updated. The large international circulation of this journal reflects its importance.
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