Katharina Seystahl, Juliane Schweizer, Mira Katan, Sung Ju Weber, Alessia Hug, Miriam Wanner, Andreas R Luft, Sabine Rohrmann, Susanne Wegener, Michael Weller
{"title":"癌症和非癌症患者的卒中相关感染。","authors":"Katharina Seystahl, Juliane Schweizer, Mira Katan, Sung Ju Weber, Alessia Hug, Miriam Wanner, Andreas R Luft, Sabine Rohrmann, Susanne Wegener, Michael Weller","doi":"10.1093/nop/npac075","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cancer in stroke patients is associated with higher levels of inflammatory biomarkers and unfavorable poststroke outcomes. We thus explored whether there is a link between cancer and stroke-associated infections.</p><p><strong>Methods: </strong>Medical records of patients with ischemic stroke in 2014-2016 registered in the Swiss Stroke Registry of Zurich were retrospectively analyzed. Incidence, characteristics, treatment, and outcome of stroke-associated infections diagnosed within 7 days after stroke onset were tested for an association with cancer.</p><p><strong>Results: </strong>Among 1181 patients with ischemic stroke, 102 patients with cancer were identified. Stroke-associated infections occurred in 179 and 19 patients (17% and 19%) without and with cancer (<i>P</i> = .60), respectively, among them pneumonia in 95 and 10 patients (9% and 10%) and urinary tract infections in 68 and 9 patients (6% and 9%) (<i>P</i> = .74 and <i>P</i> = .32). Use of antibiotics was similar between groups. Levels of C-reactive protein (CRP) (<i>P</i> < .001), erythrocyte sedimentation rate (ESR) (<i>P</i> = .014) and procalcitonin (<i>P</i> = .015) were higher and levels of albumin (<i>P</i> = .042) and protein (<i>P</i> = .031) were lower in patients with cancer than without cancer. Among patients without cancer, higher CRP (<i>P</i> < .001), ESR (<i>P</i> < .001) and procalcitonin (<i>P</i> = .04) and lower albumin (<i>P</i> < .001) were associated with stroke-associated infections. Among cancer patients with or without infections, no significant differences in these parameters were observed. In-hospital mortality was associated with cancer (<i>P</i> < .001) and with stroke-associated infections (<i>P</i> < .001). However, among patients with stroke-associated infections, cancer was not associated with in-hospital mortality (<i>P</i> = .24) or 30-day mortality (<i>P</i> = .66).</p><p><strong>Conclusions: </strong>Cancer does not represent a risk factor for stroke-associated infections in this patient cohort.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":"10 2","pages":"176-185"},"PeriodicalIF":2.4000,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037946/pdf/npac075.pdf","citationCount":"1","resultStr":"{\"title\":\"Stroke-associated infections in patients with and without cancer.\",\"authors\":\"Katharina Seystahl, Juliane Schweizer, Mira Katan, Sung Ju Weber, Alessia Hug, Miriam Wanner, Andreas R Luft, Sabine Rohrmann, Susanne Wegener, Michael Weller\",\"doi\":\"10.1093/nop/npac075\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cancer in stroke patients is associated with higher levels of inflammatory biomarkers and unfavorable poststroke outcomes. We thus explored whether there is a link between cancer and stroke-associated infections.</p><p><strong>Methods: </strong>Medical records of patients with ischemic stroke in 2014-2016 registered in the Swiss Stroke Registry of Zurich were retrospectively analyzed. Incidence, characteristics, treatment, and outcome of stroke-associated infections diagnosed within 7 days after stroke onset were tested for an association with cancer.</p><p><strong>Results: </strong>Among 1181 patients with ischemic stroke, 102 patients with cancer were identified. Stroke-associated infections occurred in 179 and 19 patients (17% and 19%) without and with cancer (<i>P</i> = .60), respectively, among them pneumonia in 95 and 10 patients (9% and 10%) and urinary tract infections in 68 and 9 patients (6% and 9%) (<i>P</i> = .74 and <i>P</i> = .32). Use of antibiotics was similar between groups. Levels of C-reactive protein (CRP) (<i>P</i> < .001), erythrocyte sedimentation rate (ESR) (<i>P</i> = .014) and procalcitonin (<i>P</i> = .015) were higher and levels of albumin (<i>P</i> = .042) and protein (<i>P</i> = .031) were lower in patients with cancer than without cancer. Among patients without cancer, higher CRP (<i>P</i> < .001), ESR (<i>P</i> < .001) and procalcitonin (<i>P</i> = .04) and lower albumin (<i>P</i> < .001) were associated with stroke-associated infections. Among cancer patients with or without infections, no significant differences in these parameters were observed. In-hospital mortality was associated with cancer (<i>P</i> < .001) and with stroke-associated infections (<i>P</i> < .001). However, among patients with stroke-associated infections, cancer was not associated with in-hospital mortality (<i>P</i> = .24) or 30-day mortality (<i>P</i> = .66).</p><p><strong>Conclusions: </strong>Cancer does not represent a risk factor for stroke-associated infections in this patient cohort.</p>\",\"PeriodicalId\":19234,\"journal\":{\"name\":\"Neuro-oncology practice\",\"volume\":\"10 2\",\"pages\":\"176-185\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2022-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10037946/pdf/npac075.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuro-oncology practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/nop/npac075\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuro-oncology practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/nop/npac075","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/4/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Stroke-associated infections in patients with and without cancer.
Background: Cancer in stroke patients is associated with higher levels of inflammatory biomarkers and unfavorable poststroke outcomes. We thus explored whether there is a link between cancer and stroke-associated infections.
Methods: Medical records of patients with ischemic stroke in 2014-2016 registered in the Swiss Stroke Registry of Zurich were retrospectively analyzed. Incidence, characteristics, treatment, and outcome of stroke-associated infections diagnosed within 7 days after stroke onset were tested for an association with cancer.
Results: Among 1181 patients with ischemic stroke, 102 patients with cancer were identified. Stroke-associated infections occurred in 179 and 19 patients (17% and 19%) without and with cancer (P = .60), respectively, among them pneumonia in 95 and 10 patients (9% and 10%) and urinary tract infections in 68 and 9 patients (6% and 9%) (P = .74 and P = .32). Use of antibiotics was similar between groups. Levels of C-reactive protein (CRP) (P < .001), erythrocyte sedimentation rate (ESR) (P = .014) and procalcitonin (P = .015) were higher and levels of albumin (P = .042) and protein (P = .031) were lower in patients with cancer than without cancer. Among patients without cancer, higher CRP (P < .001), ESR (P < .001) and procalcitonin (P = .04) and lower albumin (P < .001) were associated with stroke-associated infections. Among cancer patients with or without infections, no significant differences in these parameters were observed. In-hospital mortality was associated with cancer (P < .001) and with stroke-associated infections (P < .001). However, among patients with stroke-associated infections, cancer was not associated with in-hospital mortality (P = .24) or 30-day mortality (P = .66).
Conclusions: Cancer does not represent a risk factor for stroke-associated infections in this patient cohort.
期刊介绍：
Neuro-Oncology Practice focuses on the clinical aspects of the subspecialty for practicing clinicians and healthcare specialists from a variety of disciplines including physicians, nurses, physical/occupational therapists, neuropsychologists, and palliative care specialists, who have focused their careers on clinical patient care and who want to apply the latest treatment advances to their practice. These include: Applying new trial results to improve standards of patient care Translating scientific advances such as tumor molecular profiling and advanced imaging into clinical treatment decision making and personalized brain tumor therapies Raising awareness of basic, translational and clinical research in areas of symptom management, survivorship, neurocognitive function, end of life issues and caregiving
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