病前认知功能影响多发性硬化症患者自述认知困难与认知评估之间的差异。

IF 2 4区心理学 Q2 PSYCHOLOGY

Journal of Neuropsychology Pub Date : 2023-05-22 DOI:10.1111/jnp.12327

Clara Stein, Fiadhnait O'Keeffe, Caoimhe McManus, Niall Tubridy, Maria Gaughan, Christopher McGuigan, Jessica Bramham

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引用次数: 0

摘要

据报告，多发性硬化症患者（pwMS）中有 60% 存在认知困难。自我报告的认知困难与认知评估结果之间往往存在差异。其中一些差异可以用抑郁和疲劳来解释。在解释自我报告的认知能力和评估的认知能力之间的差异时，MS 前的认知能力可能是另一个重要的变量。估计病前认知功能（ePCF）较高的 PwMS 可能会在日常生活中注意到认知困难，同时在认知评估中表现在平均范围内。我们假设，考虑到抑郁和疲劳，ePCF 将预测（1）自我报告的认知能力与评估的认知能力之间的差异，以及（2）认知评估的表现。我们探讨了 ePCF 是否能预测 (3) 自我报告的认知困难。87 名患者完成了病前功能测试 (TOPF)、多发性硬化症简易国际认知评估 (BICAMS)、认知困难自我报告测量（多发性硬化症神经心理学问卷；MSNQ）、疲劳（多发性硬化症疲劳影响量表；MFIS）和抑郁（医院焦虑抑郁量表；HADS）。结果显示，考虑到协变量，ePCF 预测了 (1) 自我报告的认知能力与评估的认知能力之间的差异，p

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Premorbid cognitive functioning influences differences between self-reported cognitive difficulties and cognitive assessment in multiple sclerosis

Cognitive difficulties are reported in up to 60% of people with MS (pwMS). There is often a discrepancy between self-reported cognitive difficulties and performance on cognitive assessments. Some of this discrepancy can be explained by depression and fatigue. Pre-MS cognitive abilities may be another important variable in explaining differences between self-reported and assessed cognitive abilities. PwMS with high estimated premorbid cognitive functioning (ePCF) may notice cognitive difficulties in daily life whilst performing within the average range on cognitive assessments. We hypothesised that, taking into account depression and fatigue, ePCF would predict (1) differences between self-reported and assessed cognitive abilities and (2) performance on cognitive assessments. We explored whether ePCF predicted (3) self-reported cognitive difficulties. Eighty-seven pwMS completed the Test of Premorbid Functioning (TOPF), the Brief International Cognitive Assessment for MS (BICAMS), self-report measures of cognitive difficulty (MS Neuropsychological Questionnaire; MSNQ), fatigue (MS Fatigue Impact Scale; MFIS) and depression (Hospital Anxiety and Depression Scale; HADS). Results revealed that, taking into account covariates, ePCF predicted (1) differences between self-reported and assessed cognitive abilities, p < .001 (model explained 29.35% of variance), and (2) performance on cognitive assessments, p < .001 (model explained 46.00% of variance), but not (3) self-reported cognitive difficulties, p = .545 (model explained 35.10% of variance). These results provide new and unique insights into predictors of the frequently observed discrepancy between self-reported and assessed cognitive abilities for pwMS. These findings have important implications for clinical practice, including the importance of exploring premorbid factors in self-reported experience of cognitive difficulties.

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来源期刊

Journal of Neuropsychology 医学-心理学

CiteScore

4.50

自引率

4.50%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.