脑癌和神经系统疾病的体液流动。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Peng Jin, Jennifer M Munson
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引用次数: 2

摘要

间质液(IF)和脑脊液(CSF)是大脑不可分割的一部分,起到缓冲和保护脑实质细胞免受损伤的作用,并有助于它们的功能。脑中脑含有各种离子、营养物质、废物、多肽、激素和神经递质。脑脊液主要通过压力依赖的大流量通过脑实质,流入脑脊液。脑室和蛛网膜下腔充满脑脊液,脑脊液通过血管周围腔循环。它也流入中频空间,部分由水通道蛋白调节,通过中频-脑脊液混合过程去除废溶质。在疾病发展过程中,这些液体的组成、流量和体积发生变化,并可能导致脑细胞功能障碍。随着成像技术的进步和基因组图谱的帮助,已经可以从脑液中获得更多的信息;然而,CSF和IF在脑癌和神经生物学疾病中的作用仍然有限。在这里,我们概述了基于我们对其动力学和组成的理解,我们在癌症和神经退行性疾病中脑液流动的知识的最新进展。本文分类为:癌症>生物医学工程神经系统疾病>生物医学工程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fluids and flows in brain cancer and neurological disorders.

Fluids and flows in brain cancer and neurological disorders.

Fluids and flows in brain cancer and neurological disorders.

Fluids and flows in brain cancer and neurological disorders.

Interstitial fluid (IF) and cerebrospinal fluid (CSF) are an integral part of the brain, serving to cushion and protect the brain parenchymal cells against damage and aid in their function. The brain IF contains various ions, nutrients, waste products, peptides, hormones, and neurotransmitters. IF moves primarily by pressure-dependent bulk flow through brain parenchyma, draining into the ventricular CSF. The brain ventricles and subarachnoid spaces are filled with CSF which circulates through the perivascular spaces. It also flows into the IF space regulated, in part, by aquaporin channels, removing waste solutes through a process of IF-CSF mixing. During disease development, the composition, flow, and volume of these fluids changes and can lead to brain cell dysfunction. With the improvement of imaging technology and the help of genomic profiling, more information has been and can be obtained from brain fluids; however, the role of CSF and IF in brain cancer and neurobiological disease is still limited. Here we outline recent advances of our knowledge of brain fluid flow in cancer and neurodegenerative disease based on our understanding of its dynamics and composition. This article is categorized under: Cancer > Biomedical Engineering Neurological Diseases > Biomedical Engineering.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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