高抗性淀粉米饭对2型糖尿病患者餐后血糖、胰岛素和肠促胰岛素的影响

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Yuta Nakamura, Ayaka Takemoto, Takeshi Oyanagi, Shingo Tsunemi, Yui Kubo, Tomoko Nakagawa, Yoshio Nagai, Yashushi Tanaka, Masakatsu Sone
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引用次数: 0

摘要

背景与目的:水稻中抗性淀粉的研究很少。日本冲绳科学技术大学院(OIST)开发出一种富含抗性淀粉的新型水稻(OIST水稻,OR)。本研究旨在阐明OR对餐后血糖浓度的影响。方法和研究设计:这项单中心、开放、随机、交叉比较研究纳入了17例2型糖尿病患者。所有参与者都完成了使用OR和白米(WR)的两餐耐受性测试。结果:参与者年龄中位数为70.0[59.0-73.0]岁,平均体重指数为25.9±3.1 kg/m2。2型糖尿病患者的血糖曲线下总面积(AUC)差值为-8223(95%可信区间[CI]: -10100 ~ -6346)。结论:与不依赖胰岛素分泌的WR相比,OR可以作为米粒摄入,显著降低餐后血糖。OR不仅可以从上小肠逃过吸收也可以从下小肠逃过吸收。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of cooked rice containing high resistant starch on postprandial plasma glucose, insulin, and incretin in patients with type 2 diabetes.

Background and objectives: Few studies exist on resistant starch in rice grains. The Okinawa Institute of Science and Technology Graduate University (OIST) has developed a new rice (OIST rice, OR) rich in resistant starch. This study aimed to clarify the effect of OR on postprandial glucose concentrations.

Methods and study design: This single-center, open, randomized, crossover comparative study included 17 patients with type 2 diabetes. All participants completed two meal tolerance tests using OR and white rice (WR).

Results: The median age of the participants was 70.0 [59.0-73.0] years, and the mean body mass index was 25.9±3.1 kg/m2. The difference in total area under the curve (AUC) of plasma glucose was -8223 (95% confidence interval [CI]: -10100 to -6346, p<0.001) mg·min/dL. The postprandial plasma glucose was significantly lower with OR than with WR. The difference in the AUC of insulin was -1139 (95% CI: -1839 to -438, p=0.004) µU·min/mL. The difference in the AUC of total gastric inhibitory peptide (GIP) and total glucagon-like peptide-1 (GLP-1) was -4886 (95% CI: -8456 to -1317, p=0.011) and -171 (95% CI: -1034 to 691, p=0.673) pmol·min/L, respectively.

Conclusions: OR can be ingested as rice grains and significantly reduced postprandial plasma glucose compared to WR independent of insulin secretion in patients with type 2 diabetes. OR could have escaped absorption not only from the upper small intestine but also from the lower small intestine.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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