植物化学物质:2019冠状病毒病治疗的潜在先导化合物

S. Kashyap, Revathy Nadhan, D. Dhanasekaran
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引用次数: 1

摘要

2019冠状病毒病(COVID-19)是由严重急性呼吸系统综合征冠状病毒2 (SARS- CoV-2)引起的全球大流行疾病。这种高度传染性感染的病例数量不断增加,迫切需要找到有效的治疗方法。SARS-CoV-2的生命周期包括病毒进入、病毒复制、病毒组装和释放。与病毒感染相关的症状常常导致致命的结果,如肺炎、心肌炎、急性呼吸窘迫综合征、高凝和/或多器官衰竭。最近的研究报告称,大黄素、表没食子儿茶素没食子酸酯和小檗碱等植物化学物质可以适度抑制SARS-CoV-2生命周期的不同阶段。这些植物化学物质已被证明通过阻断病毒表面刺突蛋白与进入受体血管紧张素转换酶(ACE2)的结合,抑制病毒与宿主细胞的膜融合,抑制参与病毒复制的RNA依赖性RNA聚合酶和/或体外病理宿主反应来破坏病毒感染和复制。本综述的重点是评估这些植物化学物质在抑制SARS-CoV-2病毒感染、生长或疾病进展方面的功效,并为这些植物化学物质在开发针对SARS-CoV-2的新疗法中的潜在用途提供一个视角
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phytochemicals: Potential Lead Compounds for COVID-19 Therapeutics
Coronavirus Disease 2019 (COVID-19) is a global pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2). The rising number of cases of this highly transmissible infection has pressed for the urgent need to find effective therapeutics. The life cycle of SARS-CoV-2 includes the viral entry, viral replication, viral assembly and release. The symptoms associated with viral infection often leads to fatal outcome with pneumonia, myocarditis, acute respiratory distress syndrome, hypercoagulability, and/or multi-organ failure. Recent studies have reported that phytochemicals such as emodin, epigallocatechin gallate, and berberine could, albeit modestly, inhibit different stages of SARS-CoV-2 life cycle. The phytochemicals have been shown to disrupt viral infection and replication by blocking viral-surface spike protein binding to entry receptor angiotensin-converting enzyme (ACE2), inhibiting viral membrane fusion with host cells, inhibiting RNA-dependent RNA polymerase involved in viral replication, and/or pathological host- responses in vitro. The focus of this review is to evaluate the efficacies of these phytochemicals on inhibiting SARS-CoV-2 viral infection, growth, or disease progression as well as to provide a perspective on the potential use of these phytochemicals in the development of novel therapeutics against SARS-CoV-2
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