弥漫性中线胶质瘤的治疗进展。

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Current Neurology and Neuroscience Reports Pub Date : 2023-12-01 Epub Date: 2023-11-03 DOI:10.1007/s11910-023-01317-8

Chantel Cacciotti, Karen D Wright

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引用次数: 0

摘要

综述目的：弥漫性中线胶质瘤（DMGs）通常预后不良，发生在儿童时期，涉及中枢神经系统的中线结构，包括丘脑、脑桥和脊髓。最近的发现：迄今为止，辐照已被证明是DMG的唯一有益治疗方法。各种基因修饰已被证明在这种疾病的发病机制中发挥作用。目前的治疗策略包括靶向表观遗传失调、细胞周期、特异性遗传改变和免疫微环境。在此，我们回顾了这种疾病的复杂特征，因为它与当前和过去的治疗方法有关。

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Advances in Treatment of Diffuse Midline Gliomas.

Purpose of review: Diffuse midline gliomas (DMGs) generally carry a poor prognosis, occur during childhood, and involve midline structures of the central nervous system, including the thalamus, pons, and spinal cord.

Recent findings: To date, irradiation has been shown to be the only beneficial treatment for DMG. Various genetic modifications have been shown to play a role in the pathogenesis of this disease. Current treatment strategies span targeting epigenetic dysregulation, cell cycle, specific genetic alterations, and the immune microenvironment. Herein, we review the complex features of this disease as it relates to current and past therapeutic approaches.

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.