Michael S. Cowled, John A. Kalaitzis, Andrew Crombie, Rachel Chen, Nicolau Sbaraini, Ernest Lacey and Andrew M. Piggott*,
{"title":"巴西青霉和诺米曲霉菌的真菌决斗导致米托司罗胺A和Kitrinomycin A的双重诱导","authors":"Michael S. Cowled, John A. Kalaitzis, Andrew Crombie, Rachel Chen, Nicolau Sbaraini, Ernest Lacey and Andrew M. Piggott*, ","doi":"10.1021/acs.jnatprod.3c00593","DOIUrl":null,"url":null,"abstract":"<p >Cocultivation of the fungi <i>Penicillium brasilianum</i> MST-FP1927 and <i>Aspergillus nomius</i> MST-FP2004 resulted in the reciprocal induction of two new compounds, miktospiromide A (<b>1</b>) from <i>A</i>. <i>nomius</i> and kitrinomycin A (<b>2</b>) from <i>P</i>. <i>brasilianum</i>. A third new compound, kitrinomycin B (<b>3</b>), was also identified from an axenic culture of <i>P</i>. <i>brasilianum</i>, along with the previously reported compounds austalide K (<b>4</b>), 17<i>S</i>-dihydroaustalide K (<b>5</b>), verruculogen (<b>6</b>), and fumitremorgin B (<b>7</b>). The structures of <b>1</b>–<b>3</b> were elucidated by detailed spectroscopic analysis and DFT calculations, while <b>4</b>–<b>7</b> were identified by comparison to authentic standards. The genome of <i>A</i>. <i>nomius</i> MST-FP2004 was sequenced, and a putative biosynthetic gene cluster for <b>1</b> was identified. Compound <b>2</b> showed activity against murine melanoma NS-1 cells (LD<sub>99</sub> 7.8 μM) and the bovine parasite <i>Tritrichomonas foetus</i> (LD<sub>99</sub> 4.8 μM).</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"86 10","pages":"2398–2406"},"PeriodicalIF":3.3000,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fungal Duel between Penicillium brasilianum and Aspergillus nomius Results in Dual Induction of Miktospiromide A and Kitrinomycin A\",\"authors\":\"Michael S. Cowled, John A. Kalaitzis, Andrew Crombie, Rachel Chen, Nicolau Sbaraini, Ernest Lacey and Andrew M. Piggott*, \",\"doi\":\"10.1021/acs.jnatprod.3c00593\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Cocultivation of the fungi <i>Penicillium brasilianum</i> MST-FP1927 and <i>Aspergillus nomius</i> MST-FP2004 resulted in the reciprocal induction of two new compounds, miktospiromide A (<b>1</b>) from <i>A</i>. <i>nomius</i> and kitrinomycin A (<b>2</b>) from <i>P</i>. <i>brasilianum</i>. A third new compound, kitrinomycin B (<b>3</b>), was also identified from an axenic culture of <i>P</i>. <i>brasilianum</i>, along with the previously reported compounds austalide K (<b>4</b>), 17<i>S</i>-dihydroaustalide K (<b>5</b>), verruculogen (<b>6</b>), and fumitremorgin B (<b>7</b>). The structures of <b>1</b>–<b>3</b> were elucidated by detailed spectroscopic analysis and DFT calculations, while <b>4</b>–<b>7</b> were identified by comparison to authentic standards. The genome of <i>A</i>. <i>nomius</i> MST-FP2004 was sequenced, and a putative biosynthetic gene cluster for <b>1</b> was identified. Compound <b>2</b> showed activity against murine melanoma NS-1 cells (LD<sub>99</sub> 7.8 μM) and the bovine parasite <i>Tritrichomonas foetus</i> (LD<sub>99</sub> 4.8 μM).</p>\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":\"86 10\",\"pages\":\"2398–2406\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2023-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c00593\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c00593","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Fungal Duel between Penicillium brasilianum and Aspergillus nomius Results in Dual Induction of Miktospiromide A and Kitrinomycin A
Cocultivation of the fungi Penicillium brasilianum MST-FP1927 and Aspergillus nomius MST-FP2004 resulted in the reciprocal induction of two new compounds, miktospiromide A (1) from A. nomius and kitrinomycin A (2) from P. brasilianum. A third new compound, kitrinomycin B (3), was also identified from an axenic culture of P. brasilianum, along with the previously reported compounds austalide K (4), 17S-dihydroaustalide K (5), verruculogen (6), and fumitremorgin B (7). The structures of 1–3 were elucidated by detailed spectroscopic analysis and DFT calculations, while 4–7 were identified by comparison to authentic standards. The genome of A. nomius MST-FP2004 was sequenced, and a putative biosynthetic gene cluster for 1 was identified. Compound 2 showed activity against murine melanoma NS-1 cells (LD99 7.8 μM) and the bovine parasite Tritrichomonas foetus (LD99 4.8 μM).
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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