探索影响遗忘性轻度认知障碍患者对公共事件逆行记忆的机制:一项纵向更新

IF 2 4区 心理学 Q2 PSYCHOLOGY
Maria Stefania De Simone, Marta Rodini, Massimo De Tollis, Carlo Caltagirone, Giovanni Augusto Carlesimo
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引用次数: 1

摘要

在这里,我们研究了影响健忘性轻度认知障碍(a- mci)逆行记忆的机制,作为纵向临床结果的函数。在随后的3年随访中,8名转换为阿尔茨海默氏痴呆(AD)的a- mci(转换型a- mci)和10名在同一时期临床保持稳定的a- mci(稳定型a- mci)在基线评估时(即当他们被诊断为a- mci时)进行比较,使用公共事件远程记忆问卷,可以理清存储和检索机制对表现准确性的差异贡献。结果表明,远程记忆缺陷主要由稳定型a-MCI的检索能力受损和转换型- ad型a-MCI的存储能力受损来解释。稳定型a-MCI中由于痕量利用缺陷而导致的逆行性遗忘与转换型a-MCI中由于痕量存储缺陷而导致的逆行性遗忘之间的区别,与在疾病进展为AD的过程中逆行性记忆下降的时间展开是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring mechanisms that affect retrograde memory for public events in amnestic mild cognitive impairment: A longitudinal update

Here, we examined mechanisms that affect retrograde memory in amnestic mild cognitive impairment (a-MCI) as a function of longitudinal clinical outcome. 8 a-MCI who converted to Alzheimer's dementia (AD) during the subsequent 3-year follow-up (converter a-MCI) and 10 a-MCI who remained clinically stable during the same period (stable a-MCI) were compared at the baseline evaluation (i.e., when they were diagnosed as a-MCI) using a remote memory questionnaire for public events that allows disentangling the differential contribution of storage and retrieval mechanisms to performance accuracy. Results suggest that deficits in remote memory are primarily explained by impaired retrieval abilities in stable a-MCI and by impaired storage in converter-to-AD a-MCI. This distinction between retrograde amnesia due to defective trace utilisation in stable a-MCI and trace storage in converter a-MCI is consistent with the temporal unfolding of declining anterograde memory over the course of disease progression to AD.

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来源期刊
Journal of Neuropsychology
Journal of Neuropsychology 医学-心理学
CiteScore
4.50
自引率
4.50%
发文量
34
审稿时长
>12 weeks
期刊介绍: The Journal of Neuropsychology publishes original contributions to scientific knowledge in neuropsychology including: • clinical and research studies with neurological, psychiatric and psychological patient populations in all age groups • behavioural or pharmacological treatment regimes • cognitive experimentation and neuroimaging • multidisciplinary approach embracing areas such as developmental psychology, neurology, psychiatry, physiology, endocrinology, pharmacology and imaging science The following types of paper are invited: • papers reporting original empirical investigations • theoretical papers; provided that these are sufficiently related to empirical data • review articles, which need not be exhaustive, but which should give an interpretation of the state of research in a given field and, where appropriate, identify its clinical implications • brief reports and comments • case reports • fast-track papers (included in the issue following acceptation) reaction and rebuttals (short reactions to publications in JNP followed by an invited rebuttal of the original authors) • special issues.
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