自闭症谱系障碍儿童在迷你篮球训练项目后,功能和结构连接的降低与核心症状的改善有关。

IF 3.2 2区 心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL
Dongyue Zhou, Zhimei Liu, Guanyu Gong, Yunge Zhang, Lin Lin, Kelong Cai, Huashuai Xu, Fengyu Cong, Huanjie Li, Aiguo Chen
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引用次数: 0

摘要

运动干预已被证明有助于改善自闭症谱系障碍(ASD)的核心症状。然而,根本机制尚未完全了解。在本研究中,我们对ASD儿童进行了为期12周的迷你篮球训练计划(MBTP),并检查了运动干预前后大脑功能和结构网络的变化。我们应用基于个体的方法构建了功能网络和结构形态网络,并研究了它们在MBTP后的变化及其与核心症状变化的关系。结构MRI和静息状态功能MRI数据来自58名3-12岁的ASD儿童(实验组:n = 32,对照组:n = 26)。与没有特殊干预的对照组相比,接受MBTP干预的ASD儿童表现出几种可区分的变化。其中包括感觉运动网络(SM)内以及SM和显著性网络之间的功能连接降低,以左颞下回为中心的皮层皮层网络和以左尾状核为中心的皮质下皮层网络的形态学连接强度降低。特别是,MBTP诱导的上述功能和结构变化与ASD的核心症状有关。我们的研究结果表明,MBTP干预可能是改善ASD儿童核心症状、降低结构和功能网络连接的有效方法,并可能推动大脑向正常神经解剖学转变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program.

Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program.

Exercise intervention has been proven helpful to ameliorate core symptoms of Autism Spectrum Disorder (ASD). However, the underlying mechanisms are not fully understood. In this study, we carried out a 12-week mini-basketball training program (MBTP) on ASD children and examined the changes of brain functional and structural networks before and after exercise intervention. We applied individual-based method to construct functional network and structural morphological network, and investigated their alterations following MBTP as well as their associations with the change in core symptom. Structural MRI and resting-state functional MRI data were obtained from 58 ASD children aged 3-12 years (experiment group: n = 32, control group: n = 26). ASD children who received MBTP intervention showed several distinguishable alternations compared to the control without special intervention. These included decreased functional connectivity within the sensorimotor network (SM) and between SM and the salience network, decreased morphological connectivity strength in a cortical-cortical network centered on the left inferior temporal gyrus, and a subcortical-cortical network centered on the left caudate. Particularly, the aforementioned functional and structural changes induced by MBTP were associated with core symptoms of ASD. Our findings suggested that MBTP intervention could be an effective approach to improve core symptoms in ASD children, decrease connectivity in both structure and function networks, and may drive the brain change towards normal-like neuroanatomy.

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来源期刊
CiteScore
8.00
自引率
10.30%
发文量
433
期刊介绍: The Journal of Autism and Developmental Disorders seeks to advance theoretical and applied research as well as examine and evaluate clinical diagnoses and treatments for autism and related disabilities. JADD encourages research submissions on the causes of ASDs and related disorders, including genetic, immunological, and environmental factors; diagnosis and assessment tools (e.g., for early detection as well as behavioral and communications characteristics); and prevention and treatment options. Sample topics include: Social responsiveness in young children with autism Advances in diagnosing and reporting autism Omega-3 fatty acids to treat autism symptoms Parental and child adherence to behavioral and medical treatments for autism Increasing independent task completion by students with autism spectrum disorder Does laughter differ in children with autism? Predicting ASD diagnosis and social impairment in younger siblings of children with autism The effects of psychotropic and nonpsychotropic medication with adolescents and adults with ASD Increasing independence for individuals with ASDs Group interventions to promote social skills in school-aged children with ASDs Standard diagnostic measures for ASDs Substance abuse in adults with autism Differentiating between ADHD and autism symptoms Social competence and social skills training and interventions for children with ASDs Therapeutic horseback riding and social functioning in children with autism Authors and readers of the Journal of Autism and Developmental Disorders include sch olars, researchers, professionals, policy makers, and graduate students from a broad range of cross-disciplines, including developmental, clinical child, and school psychology; pediatrics; psychiatry; education; social work and counseling; speech, communication, and physical therapy; medicine and neuroscience; and public health.
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