在Sex@Brain研究中,强迫性性行为障碍男性中基于体素形态学和静息状态功能连接的改变。

IF 6.6 1区 医学 Q1 PSYCHIATRY
Journal of Behavioral Addictions Pub Date : 2023-10-24 Print Date: 2023-12-22 DOI:10.1556/2006.2023.00056
Jannis Engel, Athina Gkavanozi, Maria Veit, Jonas Kneer, Tillmann H C Kruger, Christopher Sinke
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引用次数: 0

摘要

目的:强迫性行为障碍(CSBD)是ICD-11中的一个新类别。对大脑潜在机制的研究很少。对神经生物学差异的研究有助于推进新的诊断方法和治疗方法的可能性。本研究旨在检测CSBD患者的脑物质体积和静息状态功能连接(rs-FC)。方法:收集30名CSBD患者和32名年龄和教育程度匹配的对照组的结构和rs-FC磁共振成像和问卷数据。分析了先验定义种子中基于全脑体素的形态计量学(VBM)和基于种子的rs FC。结果:结构分析显示,患有CSBD的男性右小脑、枕中叶和额上叶灰质体积显著增加。当使用这些大脑结构作为rs FC的种子区域时,不能检测到rs FC的差异。相反,基于文献的rs FC分析显示,患有CSBD的男性右眶额中皮质(mOFC)和右直肌之间以及左苍白球和右中央后/中央前回之间的rs FC降低。在左侧杏仁核中,我们观察到该组楔前叶的rs FC增加。此外,这些指标大多与症状严重程度相关。结论:结构发现可能强调小脑在性唤起和CSBD中起着重要作用。也许,左侧杏仁核和楔前叶的同时激活反映了患有CSBD的男性持续的性行为。此外,CSBD中mOFC和直肌之间较低的连接性可能支持这样一种假设,即由于抑制作用降低,性刺激被更积极地评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alterations in voxel based morphometry and resting state functional connectivity in men with compulsive sexual behavior disorder in the Sex@Brain study.

Aim: Compulsive Sexual Behavior Disorder (CSBD) is a new category in ICD-11. Research examining underlying brain mechanisms is sparse. Research into neurobiological differences can be helpful in advancing the possibilities of new diagnostic approaches and therapeutic methods. The present study aimed to examine brain matter volume and resting state functional connectivity (rs-FC) in CSBD.

Methods: Structural and rs-FC magnetic resonance imaging and data from questionnaires were collected in 30 men with CSBD and 32 age- and education-matched controls. Whole brain voxel based morphometry (VBM) and seed based rs-FC in a-priori defined seeds were analyzed.

Results: Structural analyses showed that men with CSBD had significantly increased gray matter volume in the right cerebellum, middle occipital and superior frontal lobe. No differences in rs-FC could be detected when using these brain structures as seed regions in rs-FC. In contrast, literature based rs-FC analysis revealed decreased rs-FC between the right orbital middle frontal cortex (mOFC) and the right gyrus rectus, as well as between left pallidum and right post/precentral gyrus in men with CSBD. In the left amygdala we observed increased rs-FC with precuneus in this group. In addition, most of these measures correlated with symptom severity.

Conclusion: Structural findings may underscore the idea that the cerebellum plays an important role in sexual arousal and CSBD. Perhaps, a simultaneous activation of the left amygdala and the precuneus reflects a constant sexual occupation of men with CSBD. Furthermore, lower connectivity between mOFC and gyrus rectus in CSBD may support the assumption that sexual stimuli are evaluated more positively because inhibition is decreased.

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来源期刊
CiteScore
12.30
自引率
7.70%
发文量
91
审稿时长
20 weeks
期刊介绍: The aim of Journal of Behavioral Addictions is to create a forum for the scientific information exchange with regard to behavioral addictions. The journal is a broad focused interdisciplinary one that publishes manuscripts on different approaches of non-substance addictions, research reports focusing on the addictive patterns of various behaviors, especially disorders of the impulsive-compulsive spectrum, and also publishes reviews in these topics. Coverage ranges from genetic and neurobiological research through psychological and clinical psychiatric approaches to epidemiological, sociological and anthropological aspects.
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