姜黄素负载纳米药物在疟疾管理中的治疗策略

IF 4 Q2 FOOD SCIENCE & TECHNOLOGY
eFood Pub Date : 2023-09-18 DOI:10.1002/efd2.113
Ruhul Amin, Chanam Melody Devi, Dona Sarkar, Javad Sharifi-Rad, Eda Sönmez Gürer, Anca Oana Docea, Daniela Calina
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引用次数: 0

摘要

疟疾是一种广泛分布在热带气候中的寄生原生动物疾病,由疟原虫传播。许多人受到这种重要的公共卫生疾病的影响,这种疾病在全球范围内发病率和死亡率都很高。由于抗药性寄生虫正在增加,对蚊子的控制不够,也没有接种任何疟疾疫苗。疟疾在发展中国家尤其具有挑战性。经美国食品药品监督管理局批准的抗疟疾药物是防治疟疾的主要选择;在蚊子层面控制传播也很重要。目前的抗疟化疗疗法存在显著的临床缺陷,如疟原虫耐药性,这些药物需要开发新的候选药物。为了对抗疟疾,纳米技术可能会提供一种可行的替代方案,比目前的治疗方案更有效、更安全。基于纳米技术的姜黄素制剂已被证明在最佳治疗效果、安全性和成本效益方面克服了当前疗法的局限性,从而提高了患者坚持处方药的能力。本文讨论了当前疟疾疗法的局限性以及使用纳米技术姜黄素治疗疟疾的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Curcumin-loaded nanomedicines as therapeutic strategy in malaria management

Curcumin-loaded nanomedicines as therapeutic strategy in malaria management

Malaria, a parasitic protozoan disease widespread in tropical climates, is transmitted by Plasmodium spp. Many people are affected by this significant public health disease, which has a high incidence of illness and mortality worldwide. Because drug-resistant parasites are on the rise, there are not enough controls on mosquitoes, and there are not any malaria vaccinations. Malaria is particularly challenging in developing countries. Antimalarial drugs approved by Food and Drug Administration are the main options for combating and preventing malaria; also the control of transmission at the level of mosquitoes is important. Current antimalarial chemotherapeutic therapies have significant clinical flaws such as Plasmodium resistance, the drugs that call for the development of novel drug candidates. To combat malaria, nanotechnology may give a viable alternative that is both more effective and safer than current treatment options. Nanotechnology-based curcumin formulations have proved to overcome the limitations of current therapies in terms of optimum therapeutic benefits, safety, and cost-efficiency, which increases a patient's capacity to adhere to prescribed medicine. The limits of current malaria therapies and the need to employ nanotechnological curcumin to treat malaria were addressed and discussed in this paper.

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来源期刊
eFood
eFood food research-
CiteScore
6.00
自引率
0.00%
发文量
44
期刊介绍: eFood is the official journal of the International Association of Dietetic Nutrition and Safety (IADNS) which eFood aims to cover all aspects of food science and technology. The journal’s mission is to advance and disseminate knowledge of food science, and to promote and foster research into the chemistry, nutrition and safety of food worldwide, by supporting open dissemination and lively discourse about a wide range of the most important topics in global food and health. The Editors welcome original research articles, comprehensive reviews, mini review, highlights, news, short reports, perspectives and correspondences on both experimental work and policy management in relation to food chemistry, nutrition, food health and safety, etc. Research areas covered in the journal include, but are not limited to, the following: ● Food chemistry ● Nutrition ● Food safety ● Food and health ● Food technology and sustainability ● Food processing ● Sensory and consumer science ● Food microbiology ● Food toxicology ● Food packaging ● Food security ● Healthy foods ● Super foods ● Food science (general)
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