聚葡萄糖对轻度便秘健康成人粪便体积和肠道功能的影响:一项双盲安慰剂对照研究

IF 1.3 Q4 FOOD SCIENCE & TECHNOLOGY
D. Risso, Ieva Laurie, E. Sarkkinen, K. Karnik
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引用次数: 0

摘要

背景和目标。据报道,聚葡萄糖(PDX)(8-30g/天)可增加粪便体积和稠度,使粪便更容易通过。然而,关于PDX对排便频率和结肠转运时间影响的研究结果喜忧参半,大多集中在健康或高度便秘的成年人身上,这使得PDX是否以及如何帮助轻度便秘的人的问题部分没有得到解答。方法。我们研究了经历一种或多种轻度便秘症状的健康受试者服用PDX对粪便体积、脱脂频率、粪便稠度、粪便通过的容易程度和总结肠传输时间的影响,以进一步表征和产生关于这种纤维潜在有益作用的更多证据。51名受试者参加了一项为期4周、双中心、随机、双盲、安慰剂对照的平行研究,测试对照(CON)和PDX治疗(饼干和饮料混合物中含有18 g/d)(在clinicaltrials.gov上注册,标识符为“NCT05309837”),PDX组的结肠转运时间缩短了约4小时:尽管这一差异没有达到显著性(p>0.05),因为该研究未能检测到这一次要结果的统计差异,但这一结果仍然具有生理意义。PDX的摄入耐受性良好,一些PDX志愿者报告了更轻微的胀气(p<0.05)。结论。总之,我们的研究为每天适量(18克)摄入PDX如何增加粪便膨胀并可能缩短结肠传输时间提供了新的证据,使该成分成为用于配制和重新配方的良好候选者,食品和饮料,用减少的热量取代高热量的碳水化合物,丰富易于食用的食物,以增强纤维摄入并支持肠道功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of polydextrose on fecal bulk and bowel function in mildly constipated healthy adults: a double-blind, placebo controlled study
Background & Aims. Polydextrose (PDX) (8-30g/day) has been reported to increase faecal bulk and consistency, leading to easier stool passage. However, studies on its effect on defaecation frequency and colonic transit time have provided mixed results, and most focused on either healthy or highly constipated adults, leaving the question on if and how PDX could also aid mildly constipated individuals partially unanswered.Methods. We investigated the effects of PDX consumption by healthy subjects experiencing one or more symptoms of mild constipation on faecal bulk, defaecation frequency, stool consistency, ease of stool passage, and total colonic transit time to further characterize and generate additional evidence regarding the potential beneficial effects of this fibre. 51 subjects participated in a 4-week, two-center, randomized, double-blind, placebo-controlled, parallel study testing a control (CON) and a PDX treatment (18 g/d included in biscuits and drink mixtures) (registered on clinicaltrials.gov with the identifier" NCT05309837").Results. Consumption of PDX resulted in 120.7 g and 25.7 g higher faecal wet and dry weight, respectively (p < 0.05). Colonic transit time was ~4 h shorter in the PDX group: although this difference did not reach significance (p > 0.05) as the study was underpowered to detect a statistical difference for this secondary outcome, this result still carries a physiological importance. Consumption of PDX was well-tolerated, with some PDX volunteers reporting more mild flatulence (p < 0.05).Conclusions. All in all, our study adds new evidence on how a moderate (18g) daily intake of PDX could increase faecal bulking and potentially shorten colonic transit time, making this ingredient a good candidate to be used to formulate, and reformulate, foods and beverages by replacing caloric carbohydrates with reduced caloric content, enriching food items easily consumed to enhance fibre intake and support bowel function.
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来源期刊
Functional Foods in Health and Disease
Functional Foods in Health and Disease FOOD SCIENCE & TECHNOLOGY-
CiteScore
2.20
自引率
20.00%
发文量
47
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