苏丹kosti教学医院就诊人员幽门螺杆菌感染的检测、临床特征和实验室标志物

IF 1 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
M. Azoz, B. Almugadam, O. M. Ibrahim, Y. Ahmed, A. Tayeb, Noor Eshagg, R. Hassan
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引用次数: 0

摘要

背景:幽门螺杆菌感染与显著的发病率相关。这项研究旨在筛查有症状的患者中的幽门螺杆菌,并评估抗幽门螺杆菌的性能。幽门螺杆菌免疫球蛋白G(IgG)测试与粪便Ag测试的比较,以及研究幽门螺杆菌血清阳性者的一些临床和血液学发现。方法:招募100名临床怀疑幽门螺杆菌感染的个体和100名性别(χ2=0.026,P=0.873)和年龄组(χ2=5.303,P=0.151)匹配的对照受试者。临床评估,内窥镜检查,抗H。幽门螺杆菌IgG检测和粪便cagA-Ag检测来研究幽门螺杆菌感染。还分析了白细胞、红细胞(RBCs)、血红蛋白(Hb)和平均红细胞血红蛋白(MCH)。结果:研究组呕吐和吐血的报告率分别为44%和8%。然而,所有患者均出现恶心、上腹痛和体重减轻(100%)。值得注意的是,胃炎和十二指肠溃疡分别在100%和80%的病例中被检测到。根据免疫色谱测试(ICT),75%和78%的研究组抗-H呈阳性。pylori Ab和cagA-Ag。根据抗幽门螺杆菌检测结果,女性幽门螺杆菌阳性的可能性低于男性。幽门螺杆菌(比值比[OR]:0.529,95%可信区间[CI]:0.142–1.970,P:0.343)和粪便cagA-Ag试验(OR:0.364,95%CI:0.087–1.532,P:0.168)。幽门螺杆菌检测分别为77.2%、85.3%、78.7%、84.1%和81.9%。有趣的是,与研究病例相比,对照组的RBCs计数、MCH和Hb显著升高,P<0.05。结论:我们的研究结果突出了幽门螺杆菌的流行病学,评估了抗幽门螺杆菌试验与cagA-Ag试验的性能,并证明了一些血液学指标与幽门螺杆菌之间的直接联系。需要进一步的研究来验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Detection, clinical features, and laboratory markers of H.pylori infection in individuals attended kosti teaching hospital, Sudan
Background: Helicobacter pylori infections are associated with significant morbidity. The study intended to screen H. pylori among symptomatic patients and assess the performance of anti-H. pylori immunoglobulin G (IgG) test compared to stool Ag test as well as to investigate some clinical and hematology findings in H. pylori-seropositive persons. Methods: One hundred individuals with the clinical suspicion of infection by H. pylori and 100 control subjects matched for gender (χ2 = 0.026, P = 0.873) and age groups (χ2 = 5.303, P = 0.151) were recruited. Clinical assessment, endoscopy, anti-H. pylori IgG test, and stool for cagA Ag were performed to investigate H. pylori infection. White blood cells, red blood cells (RBCs), hemoglobin (Hb), and mean corpuscular hemoglobin (MCH) were also analyzed. Results: Vomiting and hematemesis were reported in 44% and 8% of the study group, respectively. Whereas, nausea, epigastric pain, and weight loss were observed in all (100%). Notably, gastritis and duodenal ulcer were detected in 100% and 80% of cases, respectively. Based on Immunochromatographic test (ICT), 75% and 78% of the study group were positive for anti-H. pylori Ab and cagA Ag of H. pylori, respectively. The odd of reported a positive result for H. pylori was less likely in females than males as determined by anti-H. pylori (odds ratio [OR]: 0.529, 95% confidence interval [CI]: 0.142–1.970, P: 0.343) and stool cagA Ag test (OR: 0.364, 95% CI: 0.087–1.532, P: 0.168). Compared to the cagA Ag test, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of anti-H. pylori test were 77.2%, 85.3%, 78.7%, 84.1%, and 81.9%, respectively. Interestingly, RBCs count, MCH, and Hb were significantly higher in the control compared to study cases, P < 0.05. Conclusions: Our results highlight the epidemiology of into H. pylori, assess the performance of anti H. pylori test compared to cagA Ag test, and demonstrate the direct link between some hematologic indices and H. pylori. Further studies are necessary to verify these findings.
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来源期刊
Biomedical and Biotechnology Research Journal
Biomedical and Biotechnology Research Journal Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.20
自引率
42.90%
发文量
24
审稿时长
11 weeks
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