花椰菜籽提取物中萝卜硫素硫甙对日本健康成人免疫系统的影响

IF 1.3 Q4 FOOD SCIENCE & TECHNOLOGY
Naoyuki Kouno, N. Suzuki, T. Takara
{"title":"花椰菜籽提取物中萝卜硫素硫甙对日本健康成人免疫系统的影响","authors":"Naoyuki Kouno, N. Suzuki, T. Takara","doi":"10.31989/ffhd.v13i6.1089","DOIUrl":null,"url":null,"abstract":"Background: The Purpose of this study was to investigate the effects of sulforaphane glucosinolate (SGS) from broccoli seed extracts on immune function and common cold symptoms in healthy Japanese adults.Methods: This randomized, placebo-controlled, double-blind, parallel-group comparison study was conducted on Japanese adults who had worse health-related quality of life on the SF-8 and were more likely to catch colds from October 22, 2020 to April 2, 2021.Individuals who agreed to participate in the study were randomly assigned to either the SGS 100 mg/day group or the placebo group (n = 33 each). The intervention lasted 8 weeks. The outcomes of this study were the cumulative and the maximum number of days for which common cold symptoms persisted during the intervention period per subject (primary), and the frequency with which subjects experienced these symptoms per group (secondary). Additionally, the incidence rate of subjects infected with the influenza virus, immune indices, and SF-8 were assessed.Results: Based on a per protocol set, 64 subjects (33 in the SGS group and 31 in the placebo group) were analyzed. After the 8-week interventional period, the cumulative number of days for which common cold symptoms per subject was significantly lower for the SGS group than the placebo group (12.1 ± 13.5 for the SGS group and 20.2 ± 18.2 for the placebo group). The cumulative number of days of common cold symptoms per group was also significantly lower in the SGS group than in the placebo group (400 days in the SGS group and 626 days in the placebo group). No changes attributable to the SGS intervention were observed in the other outcomes. There were no adverse events due to food ingestion.Conclusion: A period of 8 weeks of SGS intake was shown to alleviate the onset of common cold symptoms in healthy Japanese adults who were prone to catching colds and had a low subjective sense of wellness.Keywords: Broccoli, sulforaphane, glucoraphanin, cold symptoms, immunityTrial registration: UMIN-CTR: UMIN000042195.Foundation: Murakami Farm Co., Ltd.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of sulforaphane glucosinolates from broccoli seed extract on the immune system of healthy Japanese adults\",\"authors\":\"Naoyuki Kouno, N. Suzuki, T. Takara\",\"doi\":\"10.31989/ffhd.v13i6.1089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The Purpose of this study was to investigate the effects of sulforaphane glucosinolate (SGS) from broccoli seed extracts on immune function and common cold symptoms in healthy Japanese adults.Methods: This randomized, placebo-controlled, double-blind, parallel-group comparison study was conducted on Japanese adults who had worse health-related quality of life on the SF-8 and were more likely to catch colds from October 22, 2020 to April 2, 2021.Individuals who agreed to participate in the study were randomly assigned to either the SGS 100 mg/day group or the placebo group (n = 33 each). The intervention lasted 8 weeks. The outcomes of this study were the cumulative and the maximum number of days for which common cold symptoms persisted during the intervention period per subject (primary), and the frequency with which subjects experienced these symptoms per group (secondary). Additionally, the incidence rate of subjects infected with the influenza virus, immune indices, and SF-8 were assessed.Results: Based on a per protocol set, 64 subjects (33 in the SGS group and 31 in the placebo group) were analyzed. After the 8-week interventional period, the cumulative number of days for which common cold symptoms per subject was significantly lower for the SGS group than the placebo group (12.1 ± 13.5 for the SGS group and 20.2 ± 18.2 for the placebo group). The cumulative number of days of common cold symptoms per group was also significantly lower in the SGS group than in the placebo group (400 days in the SGS group and 626 days in the placebo group). No changes attributable to the SGS intervention were observed in the other outcomes. There were no adverse events due to food ingestion.Conclusion: A period of 8 weeks of SGS intake was shown to alleviate the onset of common cold symptoms in healthy Japanese adults who were prone to catching colds and had a low subjective sense of wellness.Keywords: Broccoli, sulforaphane, glucoraphanin, cold symptoms, immunityTrial registration: UMIN-CTR: UMIN000042195.Foundation: Murakami Farm Co., Ltd.\",\"PeriodicalId\":12623,\"journal\":{\"name\":\"Functional Foods in Health and Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Functional Foods in Health and Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31989/ffhd.v13i6.1089\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Functional Foods in Health and Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31989/ffhd.v13i6.1089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:本研究的目的是研究西兰花籽提取物中萝卜硫素硫代葡萄糖苷(SGS)对日本健康成人免疫功能和普通感冒症状的影响。方法:这项随机、安慰剂对照、双盲、平行组比较研究是在2020年10月22日至2021年4月2日期间对SF-8上健康相关生活质量较差且更容易感冒的日本成年人进行的。同意参加研究的个体被随机分配到SGS 100毫克/天组或安慰剂组(n = 33)。干预持续8周。本研究的结果是每位受试者在干预期间普通感冒症状持续的累积天数和最长天数(原发性),以及每组受试者出现这些症状的频率(继发性)。并对流感病毒感染率、免疫指标、SF-8进行评估。结果:基于每个方案集,对64名受试者(SGS组33名,安慰剂组31名)进行了分析。在8周的干预期后,SGS组每位受试者出现普通感冒症状的累计天数显著低于安慰剂组(SGS组为12.1±13.5天,安慰剂组为20.2±18.2天)。SGS组每组出现普通感冒症状的累计天数也显著低于安慰剂组(SGS组为400天,安慰剂组为626天)。在其他结果中未观察到SGS干预的变化。没有因食物摄入引起的不良事件。结论:为期8周的SGS摄入被证明可以缓解日本健康成年人的普通感冒症状,这些成年人容易感冒,主观健康感较低。关键词:西兰花,萝卜硫素,萝卜硫素,感冒症状,免疫试验注册:UMIN-CTR: UMIN000042195基金会:村上农场有限公司
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of sulforaphane glucosinolates from broccoli seed extract on the immune system of healthy Japanese adults
Background: The Purpose of this study was to investigate the effects of sulforaphane glucosinolate (SGS) from broccoli seed extracts on immune function and common cold symptoms in healthy Japanese adults.Methods: This randomized, placebo-controlled, double-blind, parallel-group comparison study was conducted on Japanese adults who had worse health-related quality of life on the SF-8 and were more likely to catch colds from October 22, 2020 to April 2, 2021.Individuals who agreed to participate in the study were randomly assigned to either the SGS 100 mg/day group or the placebo group (n = 33 each). The intervention lasted 8 weeks. The outcomes of this study were the cumulative and the maximum number of days for which common cold symptoms persisted during the intervention period per subject (primary), and the frequency with which subjects experienced these symptoms per group (secondary). Additionally, the incidence rate of subjects infected with the influenza virus, immune indices, and SF-8 were assessed.Results: Based on a per protocol set, 64 subjects (33 in the SGS group and 31 in the placebo group) were analyzed. After the 8-week interventional period, the cumulative number of days for which common cold symptoms per subject was significantly lower for the SGS group than the placebo group (12.1 ± 13.5 for the SGS group and 20.2 ± 18.2 for the placebo group). The cumulative number of days of common cold symptoms per group was also significantly lower in the SGS group than in the placebo group (400 days in the SGS group and 626 days in the placebo group). No changes attributable to the SGS intervention were observed in the other outcomes. There were no adverse events due to food ingestion.Conclusion: A period of 8 weeks of SGS intake was shown to alleviate the onset of common cold symptoms in healthy Japanese adults who were prone to catching colds and had a low subjective sense of wellness.Keywords: Broccoli, sulforaphane, glucoraphanin, cold symptoms, immunityTrial registration: UMIN-CTR: UMIN000042195.Foundation: Murakami Farm Co., Ltd.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Functional Foods in Health and Disease
Functional Foods in Health and Disease FOOD SCIENCE & TECHNOLOGY-
CiteScore
2.20
自引率
20.00%
发文量
47
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信