IL12B和INFG多态性与假剥脱综合征和青光眼风险的相关性研究

IF 1 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
G. Fakhraie, J. Ghanavi, K. Saliminejad, P. Farnia
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引用次数: 0

摘要

背景:免疫反应可能参与假剥脱性(PEX)、假剥脱型青光眼(PEXG)和原发性开角型青光眼(POAG)发病机制的发展。本研究的目的是评估伊朗人群中IL12B rs3212227 A/C和INFG rs1861494 T/C多态性与PEX、PEXG和POAG风险的相关性。方法:本研究共纳入55例POAG、57例PEX和78例PEXG患者以及79名健康对照。IL12B和INFG多态性的基因分型通过聚合酶链式反应和限制性片段长度多态性方法分别使用TaqI和FauI限制性内切酶进行。结果:结果表明,与对照组(12.6%)相比,POAG(36.4%;P<0.001;比值比[OR]=4.0,95%置信区间[CI]:1.7-10.0)和PEX患者(36.4%,P=0.023;OR=2.7,95%CI:1.1-6.9)中IL12B-AC基因型显著更高(P<0.001;OR=3.4,95%CI:3.4-7.3)。与对照组(19.0%)相比,PEX(38.6%;P=0.007;OR=2.8,95%CI:1.3-6.3)和PEXG患者(37.2%;P=0.009;OR=2.7,95%CI:1.1-6.9)的INFG TC基因型明显更高。C等位基因似乎是PEX(P=0.002;OR=2.8,95%CI:1.4-5.7)和PEXD(P=0.009;OR=2.4,95%CI:1.2-4.7)的危险因素。结论:总体而言,IL12B与POAG和PEX易感性相关,IL12BC-等位基因增加了POAG和PE的风险。此外,INFG与PEX和PEXG易感性相关,INFG C等位基因似乎是PEX和PEXG的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the association of IL12B and INFG Polymorphisms with the risk of pseudoexfoliation syndrome and glaucoma
Background: Immune responses may be involved in the development of pseudoexfoliation (PEX), pseudoexfoliation glaucoma (PEXG), and primary open-angle glaucoma (POAG) pathogenesis. The aim of the present study was to evaluate the association of IL12B rs3212227 A/C and INFG rs1861494 T/C polymorphisms with the risk of PEX, PEXG, and POAG in an Iranian population. Methods: Totally, 55 POAG, 57 PEX, and 78 PEXG patient cases as well as 79 healthy controls were included in this study. Genotyping of the IL12B and INFG polymorphisms was performed by polymerase chain reaction and restriction fragment length polymorphism methods using TaqI and FauI restriction enzyme, respectively. Results: Results indicated that IL12B AC genotype was significantly higher in POAG (36.4%; P < 0.001; odds ratio [OR] = 4.0, 95% confidence interval [CI]: 1.7–10.0) and PEX patients (36.4%; P = 0.023; OR = 2.7, 95% CI: 1.1–6.9) compared to the control group (12.6%). The C allele could be considered a risk factor for POAG (P = 0.002; OR = 3.1, 95% CI: 3.1–6.8) and PEX (P < 0.001; OR = 3.4, 95% CI: 3.4–7.3). INFG TC genotype was significantly higher in PEX (38.6%; P = 0.007; OR = 2.8, 95% CI: 1.3–6.3) and PEXG patients (37.2%; P = 0.009; OR = 2.7, 95% CI: 1.1–6.9) compared to the control group (19.0%). The C allele seemed to be a risk factor for PEX (P = 0.002; OR = 2.8, 95% CI: 1.4–5.7) and PEXG (P = 0.009; OR = 2.4, 95% CI: 1.2–4.7). Conclusion: Overall, IL12B was associated with susceptibility to POAG and PEX, and IL12B C allele increased the risk of POAG and PEX. In addition, INFG was associated with susceptibility to PEX and PEXG, and the INFG C allele seemed to be a risk factor for PEX and PEXG.
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来源期刊
Biomedical and Biotechnology Research Journal
Biomedical and Biotechnology Research Journal Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.20
自引率
42.90%
发文量
24
审稿时长
11 weeks
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