与γ-环糊精共食可提高紫苏籽油中α-亚麻酸的生物利用度

IF 4.6 Q1 CHEMISTRY, APPLIED
Keisuke Yoshikiyo , Miho Takahashi , Yu Narumiya , Mikito Honda , Keita Iwasaki , Mika Ishigaki , Edward G. Nagato , Hemanth Noothalapati , Hidehisa Shimizu , Kaeko Murota , Tatsuyuki Yamamoto
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引用次数: 3

摘要

本研究以紫苏籽为原料,以γ-环糊精(γ-CD)包合物的形式摄入紫苏油,研究了γ-CD在紫苏油同化过程中的作用。与不添加γ-CD的大鼠相比,添加该包合物的大鼠血浆α-亚麻酸(18:3n-3)水平显著升高,表明γ-CD提高了紫苏油的生物利用度。一项体外脂肪分解分析表明,紫苏油比大豆油更能抵抗猪胰腺脂肪酶,大豆油是动物饲料中常用的脂肪来源。然而,添加γ-CD加速了紫苏油的脂肪分解,这可能解释了喂食包合物的大鼠血浆中18:3n-3水平升高的原因。这些发现表明,在摄入紫苏油时,有一种更有效的方法可以提高18:3n-3和更长n-3脂肪酸的生理水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Co-ingestion with γ-cyclodextrin improves bioavailability of α-linolenic acid in Perilla frutescens seed oil

Co-ingestion with γ-cyclodextrin improves bioavailability of α-linolenic acid in Perilla frutescens seed oil

The present study aimed to determine the effects of ingesting perilla oil derived from the seeds of Perilla frutescens as an inclusion complex with γ-cyclodextrin (γ-CD) in a six-week study, and to elucidate the role of γ-CD in the assimilation of perilla oil. Plasma α-linolenic acid (18:3n-3) levels were significantly higher in rats fed a diet containing this inclusion complex compared to those fed the same amount of perilla oil without γ-CD, indicating that γ-CD enhances perilla oil bioavailability. An in vitro analysis of lipolysis revealed that perilla oil was more resistant to porcine pancreatic lipase than soybean oil, a commonly used lipid source in animal diets. However, adding γ-CD accelerated perilla oil lipolysis, which may explain the elevated 18:3n-3 plasma levels in rats fed the inclusion complex. These findings suggest a more efficient way to increase physiological levels of 18:3n-3 and longer n-3 fatty acids when ingesting perilla oil.

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来源期刊
CiteScore
4.50
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