不同天然产煤及煤介导的商业产品对临床分离病原菌的体外抗菌活性筛选

IF 1 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
S. Shreya, T. Islam, T. Ishma, Irin Polin, Fahim Nazia, M. Acharjee
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引用次数: 1

摘要

背景:由耐药菌群引起的微生物疾病的增加是最严重的公共卫生问题之一,因此确定新的抗菌药物对于对抗多重耐药菌株至关重要。方法:采用常规培养和生化检测的方法,对从达喀市Dinajpur Barapukuria煤矿和不同零售商采集的一些天然产煤和煤介导的商品进行微生物状况评估。此外,还通过琼脂孔扩散法和最低抑菌浓度(MIC)法检测了两类煤样品的抑菌潜力。结果:在10份样品中,除木炭外,所有样品的活菌总数均在高范围内。在特定细菌方面,两类样品均仅检出葡萄球菌,而煤介导的商品中检出克雷伯氏菌。两类样品均具有良好的抑菌活性,抑菌范围为9 mm ~ 26 mm。然而,通过琼脂孔扩散法,天然产煤对芽孢杆菌、志贺氏菌和弧菌的抑菌活性不明显。同时,所有样品的最小浓度都被成功地量化为MIC值,在MIC值下细菌生长受到阻碍。在天然产煤中,木煤粉对大肠杆菌的最低浓度为4 mg/ml,而最大浓度估计为34 mg/ml。相反,对于煤介导的商业产品,MIC值在4 mg/ml至24 mg/ml之间变化。结论:天然产煤及其介导产物具有良好的抗菌特性,具有治疗多种感染性疾病的经济潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Screening the in-vitro Antibacterial Activity of Different Naturally Produced Coal and Coal Mediated Commercial Products on Clinically Isolated Pathogens
Background: The rise of microbial illnesses caused by drug-resistant microflora is one of the most serious public health concerns, therefore identifying novel antimicrobial agents is crucial in combating multidrug-resistant bacterial strains. Methods: Present Investigation designated to assess the microbiological status of some naturally produced coal and coal mediated commercial products collected from Barapukuria Coal Mine Dinajpur and different retailer in Dhaka city, respectively through conventional cultural and biochemical tests. Moreover, the anti-bacterial potential of both categories of coal samples was also aimed to be checked by the agar well diffusion method and minimal inhibitory concentration (MIC) assay. Results: Out of 10 samples, total viable bacteria was estimated at high range in all the samples excluding the charcoal. In case of specific bacteria, only Staphylococcus spp. was found in both types of samples while Klebsiella spp. was found in coal mediated commercial products. Both categories of samples showed their anti-bacterial activity with satisfactory range of zone diameter (9 mm–26 mm). However, the naturally produced coal was unable to show their anti-bacterial activity against Bacillus spp., Shigella spp. and Vibrio spp. through agar well diffusion methods. Meanwhile, the minimal concentration of all the samples was successfully quantified as MIC value at which the bacterial growth was retarded. In case of naturally produced coal, the lowest concentration 4 mg/ml was recorded for wooden coal powder against Escherichia coli while the maximum concentration was estimated at 34 mg/ml. Conversely, the MIC value was varied between 4 mg/ml to 24 mg/ml in case of coal mediated commercial products. Conclusion: The results of this study suggest that the naturally produced coal and coal-mediated products have excellent antibacterial characteristics which indicating their economic potential for treating various infectious disorders.
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来源期刊
Biomedical and Biotechnology Research Journal
Biomedical and Biotechnology Research Journal Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.20
自引率
42.90%
发文量
24
审稿时长
11 weeks
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