Niladri Sekhar Chatterjee , Hema Girija Sukumaran , Pavan Kumar Dara , Balaraman Ganesan , Muhamed Ashraf , Rangasamy Anandan , Suseela Mathew , Ravishankar Chandragiri Nagarajarao
{"title":"鱼胶原膜移植琥珀酰壳聚糖水凝胶中姜黄素的纳米包封促进实验大鼠伤口愈合","authors":"Niladri Sekhar Chatterjee , Hema Girija Sukumaran , Pavan Kumar Dara , Balaraman Ganesan , Muhamed Ashraf , Rangasamy Anandan , Suseela Mathew , Ravishankar Chandragiri Nagarajarao","doi":"10.1016/j.fhfh.2022.100061","DOIUrl":null,"url":null,"abstract":"<div><p>Succinyl chitosan-fish collagen composite hydrogel containing nano-encapsulated curcumin was developed for wound healing application. Curcumin was encapsulated in succinyl chitosan nano-particles using ionic gelation technique. The <em>Z</em>-average diameter of the nanoparticles as observed by dynamic light scattering experiment was ∼47 nm. Similar size ranges were observed in atomic force microscope (AFM) and transmission electron microscopy (TEM) images. A simple one pot gelation of the composite hydrogel containing nano-encapsulated curcumin was achieved by crosslinking succinyl chitosan and fish collagen with caffeic acid. The scanning electron microscopy (SEM) images of the crosslinked hydrogel showed porous sheet like/spongy morphology typical to crosslinked hydrogels. The developed hydrogel was evaluated for its wound healing efficacy in subcutaneous wound model on Wistar albino rats. The hydrogel significantly enhanced the collagen deposition and hydroxyproline content of 599.4 μg/gm and 74.9 μg/gm in wound tissue on the 14th day of post wounding.</p></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667025922000097/pdfft?md5=b2bcecce96b9539bedc4e6a8b7f1a88c&pid=1-s2.0-S2667025922000097-main.pdf","citationCount":"12","resultStr":"{\"title\":\"Nano-encapsulation of curcumin in fish collagen grafted succinyl chitosan hydrogel accelerates wound healing process in experimental rats\",\"authors\":\"Niladri Sekhar Chatterjee , Hema Girija Sukumaran , Pavan Kumar Dara , Balaraman Ganesan , Muhamed Ashraf , Rangasamy Anandan , Suseela Mathew , Ravishankar Chandragiri Nagarajarao\",\"doi\":\"10.1016/j.fhfh.2022.100061\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Succinyl chitosan-fish collagen composite hydrogel containing nano-encapsulated curcumin was developed for wound healing application. Curcumin was encapsulated in succinyl chitosan nano-particles using ionic gelation technique. The <em>Z</em>-average diameter of the nanoparticles as observed by dynamic light scattering experiment was ∼47 nm. Similar size ranges were observed in atomic force microscope (AFM) and transmission electron microscopy (TEM) images. A simple one pot gelation of the composite hydrogel containing nano-encapsulated curcumin was achieved by crosslinking succinyl chitosan and fish collagen with caffeic acid. The scanning electron microscopy (SEM) images of the crosslinked hydrogel showed porous sheet like/spongy morphology typical to crosslinked hydrogels. The developed hydrogel was evaluated for its wound healing efficacy in subcutaneous wound model on Wistar albino rats. The hydrogel significantly enhanced the collagen deposition and hydroxyproline content of 599.4 μg/gm and 74.9 μg/gm in wound tissue on the 14th day of post wounding.</p></div>\",\"PeriodicalId\":12385,\"journal\":{\"name\":\"Food Hydrocolloids for Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667025922000097/pdfft?md5=b2bcecce96b9539bedc4e6a8b7f1a88c&pid=1-s2.0-S2667025922000097-main.pdf\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Hydrocolloids for Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667025922000097\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Hydrocolloids for Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667025922000097","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Nano-encapsulation of curcumin in fish collagen grafted succinyl chitosan hydrogel accelerates wound healing process in experimental rats
Succinyl chitosan-fish collagen composite hydrogel containing nano-encapsulated curcumin was developed for wound healing application. Curcumin was encapsulated in succinyl chitosan nano-particles using ionic gelation technique. The Z-average diameter of the nanoparticles as observed by dynamic light scattering experiment was ∼47 nm. Similar size ranges were observed in atomic force microscope (AFM) and transmission electron microscopy (TEM) images. A simple one pot gelation of the composite hydrogel containing nano-encapsulated curcumin was achieved by crosslinking succinyl chitosan and fish collagen with caffeic acid. The scanning electron microscopy (SEM) images of the crosslinked hydrogel showed porous sheet like/spongy morphology typical to crosslinked hydrogels. The developed hydrogel was evaluated for its wound healing efficacy in subcutaneous wound model on Wistar albino rats. The hydrogel significantly enhanced the collagen deposition and hydroxyproline content of 599.4 μg/gm and 74.9 μg/gm in wound tissue on the 14th day of post wounding.
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