血管生成的分子方面和生化相互作用:潜在的治疗靶点

IF 1 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Jinnenahalli Yodhaanjali, R. Achar
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引用次数: 1

摘要

血管生成是一个保守的血管生长发育的生物学过程。一种规范的血管生成方法为理解不同于癌症血管生成的分子和生化机制提供了见解。血管发芽是肿瘤转移和侵袭的关键过程,癌细胞释放一定的生长因子,激活下游信号通路,启动VEGFR2基因转录,进一步通过VEGFR2受体诱导血管生成。此外,通过这些生长因子的旁分泌信号可以直接与VEFGR2结合,使其激活。癌细胞需要几个因素来维持其生存。一段时间以来,研究表明有多种下游信号通路参与癌症预后,大多数信号通路旨在抑制内源性VEGFR2抑制分子,如血栓反应蛋白(Thrombospondin)。癌症是一种多因素疾病,因此缺氧、细胞pH值变化、代谢重编程、原癌基因和肿瘤抑制基因突变是癌细胞生长的促进因素。了解生物化学和分子机制为揭示潜在的治疗靶点铺平了道路。此外,粘附分子的作用也得到了研究,它们作为接头分子,例如αvβ6在hippo通路中激活VEGFR以促进尖端细胞活性。因此,关注血管生成的这些方面可以为开发和设计抑制性拮抗剂、癌基因靶向药物或抗癌药物提供几个靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular facets and biochemical cross-talk of angiogenesis: Potential therapeutic targets
Angiogenesis is a well conserved biological process for vascular growth and development. A canonical approach towards angiogenesis as provided insight in understanding the molecular and biochemical mechanism which differs in cancer angiogenesis. Vascular sprouting is a critical process in cancer metastasis and invasion, cancer cells release certain growth factors that can activate downstream signalling pathways to initiate VEGFR2 gene transcription further instigating angiogenesis via VEGFR2 receptors. Furthermore, paracrine signalling through these growth factor can directly bind to VEFGR2 causing its activation. There are several factors that has been procured by cancerous cells to sustain its survival. Over a period, studies have shown that there are various downstream signalling pathways taking part in cancer prognosis as most of the signalling pathways aim to inhibit endogenous VEGFR2 inhibitory molecules such as Thrombospondin. Cancer is a multifactorial disease and therefore hypoxia, changes in cellular pH, metabolic reprogramming, mutations in proto-oncogenes and tumour suppressor genes have been the contributory factors for cancer cell growth. Understanding the biochemical and molecular mechanism have paved its way in unsnarling the potential therapeutic targets. In addition, the role of adhesion molecules has also been studies they act as an adaptor molecule for an example αvβ6 in hippo pathway activates VEGFR for tip cell activity. Thereafter, focusing on these aspects of angiogenesis can provide several targets that would be used for developing and designing inhibitory antagonist, oncogene targeting drugs or anti-cancer drugs.
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来源期刊
Biomedical and Biotechnology Research Journal
Biomedical and Biotechnology Research Journal Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.20
自引率
42.90%
发文量
24
审稿时长
11 weeks
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