2019年重症急性呼吸综合征-冠状病毒-2抗原快速检测与实时逆转录-聚合酶链反应检测在实验室诊断中的成本-效用分析

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.4103/bbrj.bbrj_301_22

R. Mungmunpuntipantip, V. Wiwanitkit

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引用次数: 0

摘要

背景：2019冠状病毒病（新冠肺炎）的全球大流行仍在蔓延。因此，迫切需要快速、简单、准确的诊断方法来诊断严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）感染。为了诊断新冠肺炎病例，应调查快速SARS-CoV-2抗原检测试验的性能特征，并将其与金标准实时逆转录聚合酶链式反应（RT-PCR）试验进行比较。抗原检测测试的实用性是根据现场评估报告的。然而，一个有趣的问题是测试的效用。方法：在此，作者进行成本效用分析，以评估快速SARS-CoV-2抗原检测方法与实时RT-PCR方法在新冠肺炎实验室诊断中的比较。结果：根据分析，快速检测严重急性呼吸系统综合征冠状病毒2型抗原的每次使用成本是实时RT-PCR检测的3.24倍。结论：因此，从成本效益角度来看，快速SARS-CoV-2抗原检测法适用于诊断新冠肺炎。

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Cost–Utility analysis for rapid severe acute respiratory syndrome-coronavirus-2 antigen detection assay in comparison versus real-time reverse transcription-polymerase chain reaction assay for laboratory diagnosis of coronavirus disease -2019

Background: The global pandemic of coronavirus disease-2019 (COVID-19) is still spreading. As a result, rapid, simple, and accurate diagnostics to diagnose severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection are urgently needed. For the diagnosis of COVID-19 cases, the performance characteristics of the quick SARS-CoV-2 antigen detection test should be investigated and compared to the gold standard real-time reverse transcription-polymerase chain reaction (RT-PCR) test. The utility of the antigen detection test is reported from field evaluation. However, an interesting concern is on the utility of the test. Methods: Here, the authors perform a cost utility analysis to appraise rapid SARS-CoV-2 antigen detection assay in comparison versus real-time RT-PCR assay for laboratory diagnosis of COVID-19. Results: According to the analysis, the cost per utility of rapid SARS-CoV-2 antigen detection assay is 3.24 times less than that of comparison versus real-time RT-PCR assay. Conclusion: Hence, it can conclude that rapid SARS-CoV-2 antigen detection assay is appropriate for using for diagnosis of COVID-19 in term of cost–utility.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.