精神分裂症谱系障碍患者认知表现与临床分期的关系:一项前瞻性6年随访研究

IF 2.3 Q2 PSYCHIATRY
S. Berendsen , E. Nummenin , F. Schirmbeck , L. de Haan , M.J. van Tricht
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引用次数: 1

摘要

临床分期的发展是为了捕捉精神分裂症谱系障碍的巨大异质性。将认知表现纳入分期模型可提高分期模型的临床有效性。此外,认知功能可以预测跨阶段的过渡。然而,目前关于认知和临床分期之间关系的证据是不一致的。因此,我们的目标是评估认知参数是否与精神分裂症谱系障碍患者的临床阶段相关,并在3年和6年随访中确定基线认知标志物与阶段转换相关。方法采用Fusar-Poli等(2017)的分期模型对927例非情感性精神障碍患者进行了基线评估,并进行了3年和6年的随访。认知表现用标准测试电池进行评估。采用广义线性混合模型分析认知表现与随访阶段和阶段转换的关系。结果研究发现,病程越长,处理速度越慢(F = 3.688, p = 0.025),工作记忆缺陷越少(F = 6.365, p = 0.002)。在3年和6年的随访中,基线时的认知参数与阶段转换之间没有关联。结论加工速度和工作记忆与精神分裂症谱系障碍较高阶段的病程存在一定的相关性,从而略微提高了其临床效度。然而,关联很小,我们没有发现预测效度的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of cognitive performance with clinical staging in schizophrenia spectrum disorders: a prospective 6-year follow-up study

Background

Clinical staging has been developed to capture the large heterogeneity in schizophrenia spectrum disorders. Including cognitive performance in the staging model may improve its clinical validity. Moreover, cognitive functioning could predict transition across stages. However, current evidence of the association between cognition and clinical staging is inconsistent. Therefore, we aim to assess whether cognitive parameters are associated with clinical stages in a large sample of patients with schizophrenia spectrum disorders and to identify cognitive markers at baseline that are associated with stage-transition at three and six-year follow-up.

Methods

We applied the staging model of Fusar-Poli et al. (2017) in 927 patients with non-affective psychotic disorders, assessed at baseline, and after three and six-year follow-up. Cognitive performance was assessed with a standard test battery. Generalized linear mixed models were used to analyze associations of cognitive performance with staging and stage-transition at follow-up.

Results

Findings showed that higher stages of illness were significantly associated with lower processing speed (F = 3.688, p = 0.025) and deficits in working memory (F = 6.365, p = 0.002) across assessments. No associations between cognitive parameters at baseline and stage-transition at three- and six-year follow-up were found.

Conclusion

We conclude that processing speed and working memory were modestly associated with higher stages of illness in schizophrenia spectrum disorders, thereby slightly improving its clinical validity. However, associations were small and we found no evidence for predictive validity.

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来源期刊
CiteScore
5.60
自引率
10.70%
发文量
54
审稿时长
67 days
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