脐血单核细胞治疗新生儿缺氧缺血性脑病的研究进展。

IF 1.4 4区医学 Q4 CLINICAL NEUROLOGY

Brain & Development Pub Date : 2023-11-01 DOI:10.1016/j.braindev.2023.09.001

Jiayu Zhou, Ting Gao, Wan Tang, Tianyang Qian, Ziming Wang, Pu Xu, Laishuan Wang

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引用次数: 0

摘要

新生儿缺氧缺血性脑病（HIE）是新生儿常见疾病，是新生儿死亡和永久性神经后遗症的主要原因。治疗性低温（TH）是目前国内外临床公认有效的治疗HIE的唯一方法，但疗效有限。最近的研究表明，脐血来源的单核细胞（CB MNCs）是指脐血中含有一个细胞核的血细胞，在HIE中发挥抗氧化、抗炎、抗凋亡作用，并发挥神经保护作用。本文综述了CB MNCs治疗HIE的安全性和有效性、给药途径、剂量、时机和联合治疗。

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Progress in the treatment of neonatal hypoxic-ischemic encephalopathy with umbilical cord blood mononuclear cells

Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease among newborns, which is a leading cause of neonatal death and permanent neurological sequelae. Therapeutic hypothermia (TH) is the only method for the treatment of HIE that has been recognized effective clinically at home and abroad, but the efficacy is limited. Recent research suggests that the cord blood-derived mononuclear cells (CB-MNCs), which the refer to blood cells containing one nucleus in the cord blood, exert anti-oxidative, anti-inflammatory, anti-apoptotic effects and play a neuroprotective role in HIE. This review focuses on safety and efficacy, the route of administration, dose, timing and combination treatment of CB-MNCs in HIE.

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来源期刊

Brain & Development 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

153

审稿时长

50 days

期刊介绍： Brain and Development (ISSN 0387-7604) is the Official Journal of the Japanese Society of Child Neurology, and is aimed to promote clinical child neurology and developmental neuroscience. The journal is devoted to publishing Review Articles, Full Length Original Papers, Case Reports and Letters to the Editor in the field of Child Neurology and related sciences. Proceedings of meetings, and professional announcements will be published at the Editor''s discretion. Letters concerning articles published in Brain and Development and other relevant issues are also welcome.