TyG指数与中国成年人高血压的相关性:中国健康检查合作研究(CHEC研究)。

IF 1.3 4区 医学 Q4 NUTRITION & DIETETICS
Xue Dong, Bao Han, Weiguang Huang, Zimin Song, Ninghao Huang, Yimin Zhao, Shanshan Feng, Tao Huang
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引用次数: 0

摘要

背景和目的:我们旨在利用中国健康检查合作研究(CHEC study),研究甘油三酯-葡萄糖(TyG)指数与高血压的关系,并比较TyG指数、脂质和血糖参数对高血压的判别力。方法和研究设计:数据收集于2014年和2021年在宁波明洲医院和北京体检中心进行的CHEC研究。包括体检次数≥2次的参与者。TyG指数是空腹甘油三酯和葡萄糖的对数乘积。广义估计方程(GEE)模型用于评估TyG指数、脂质参数、血糖参数与高血压之间的相关性。采用受试者操作特征(ROC)分析,探讨TyG指数对不同体检年份高血压的预测能力。结果:本研究招募了112902名平均年龄42.8岁的参与者,36839名参与者在8年的时间里患上了高血压。GEE模型分析显示,在模型2中,TyG指数、TG/HDL-C比率、TG、TC、LDL-C、HDL-C和FPG的最高和最低五分位数中,高血压95%CI的OR分别为3.35(3.15-3.57)、1.86(1.76-1.95)、1.67(1.58-1.78)、1.45(1.33-1.58)、1.24(1.19-1.29)、0.92(0.86-0.99)和1.90(1.83-1.97)。在预测高血压方面,体检总年份的ROC曲线下面积显著高于特定年份(AUC:0.883,p 结论:TyG指数与高血压相关,与血脂和血糖参数相比,TyG指数对高血压的判别能力更强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of TyG index with hypertension in Chinese adults: the China Health Examination Collaborative Study (CHEC Study).

Background and objectives: We aimed to investigate the association of triglyceride-glucose (TyG) index with hypertension and compare the discriminative power of the TyG index, lipid, glycemic parameters for hypertension using the China Health Examination Collaborative study (CHEC Study).

Methods and study design: Data were collected at Ningbo Mingzhou Hospital and Beijing physical examination center from the CHEC Study during 2014 and 2021. Participants with ≥2 medical check-up times were included. The TyG index is the logarithmized product of fasting triglyceride and glucose. Generalised estimation equation (GEE) model was used to evaluate the association between the TyG index, lipid parameters, glycemic parameters and hypertension. Receiver operating characteristic (ROC) analysis was performed to explore the predictive ability of TyG index on hypertension at different years of medical check-up.

Results: 112,902 participants with an average age of 42.8 years were recruited in the study, 36,839 participants developed hypertension over the 8-year period. GEE model analysis showed that the ORs with 95% CI of hypertension were 3.35 (3.15-3.57), 1.86 (1.76-1.95), 1.67 (1.58-1.78), 1.45 (1.33-1.58), 1.24 (1.19-1.29), 0.92 (0.86-0.99), and 1.90 (1.83-1.97) in the highest versus lowest quintiles of TyG index, TG/HDL-C ratio, TG, TC, LDL-C, HDL-C and FPG in model 2. The area under the ROC curve of the overall years of medical check-up was signifi-cantly higher than a particular year in predicting hypertension (AUC: 0.883, p < 0.05).

Conclusions: TyG index is associated with hypertension and shows the superior discriminative ability for hypertension compared with lipid and glycemic parameters.

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来源期刊
CiteScore
2.50
自引率
7.70%
发文量
58
审稿时长
6-12 weeks
期刊介绍: The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board
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