恩替卡韦抗病毒治疗慢性乙型肝炎患者意外妊娠的安全性。

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Biomedical reports Pub Date : 2023-08-31 eCollection Date: 2023-10-01 DOI:10.3892/br.2023.1654
Lihua Cao, Shiwu Li, Jingchao Dong, Jingkui Wen, Lina Ding, Yahui Ge, Qing Yang, Xiaoyuan Xu, Hui Zhuang
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引用次数: 0

摘要

本研究旨在探讨意外妊娠慢性乙型肝炎患者在恩替卡韦(ETV)抗病毒治疗期间的生育年龄对其后代的影响。共有112对夫妇被回顾性纳入研究,他们被分为观察组和对照组。观察组共招募了53对在接受长期ETV抗病毒药物治疗时意外怀孕的夫妇。对照组由59对夫妇组成,他们在接受富马酸替诺福韦二酯(TDF)长期抗病毒治疗时意外怀孕。在观察组中,所有母亲都坚持妊娠,ETV立即被TDF取代。在对照组中,每一位母亲仍然怀孕并继续使用TDF。分娩时观察组和对照组的母婴安全状况,包括先天性残疾的患病率,具有可比性。此外,在产后28、48和96周的随访期间,没有发现新生儿的异常指征或症状。在妊娠早期和中期启动ETV或TDF对母亲和婴儿来说似乎是安全的。本研究的重要数据支持在妊娠早期和中期意外妊娠中使用ETV,并立即用TDF抗病毒药物替代ETV。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Safety of entecavir antiviral therapyduring an accidental pregnancy in patients with chronic hepatitis B.

Safety of entecavir antiviral therapyduring an accidental pregnancy in patients with chronic hepatitis B.

The present study aimed to investigate the effects of accidental pregnancy CHB patients' reproductive age on their offspring during entecavir (ETV) antiviral therapy. A total of 112 couples were retrospectively enrolled, and they were divided into an observational and control group. A total of 53 couples who had accidental pregnancies while receiving long-term ETV antiviral medication were recruited for the observational group. The control group consisted of 59 couples who became pregnant accidentally while receiving long-term tenofovir disoproxil fumarate (TDF) antiviral treatment. All mothers persisted in their pregnancies in the observational group, and ETV was promptly replaced with TDF. Every mother remained pregnant and continued to use TDF in the control group. The maternal and baby safety profiles, including the prevalence of congenital disabilities, were comparable across the observational and control groups at delivery. In addition, no unusual indications or symptoms of the newborns were noted during the follow-up intervals of 28, 48, and 96 weeks postpartum. Initiating ETV or TDF in early and middle pregnancy seems safe for mothers and infants. Important data from the present study support using ETV in early-mid gestational accidental pregnancies and the prompt substitution of TDF antiviral medication for ETV.

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来源期刊
Biomedical reports
Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
4.10
自引率
0.00%
发文量
86
期刊介绍: Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.
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