利用表面引发聚合和磷酸偶联剂提高PLA/HA复合材料的强度。

IF 1.5 4区 工程技术
Tongxin Wang, Laurence C Chow, Stanislav A Frukhtbeyn, Andy Hai Ting, Quanxiao Dong, Mingshu Yang, James W Mitchell
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引用次数: 39

摘要

由可降解聚合物(如聚乳酸(PLA))和生物活性磷酸钙(如羟基磷灰石(HA))制成的生物可吸收复合材料在临床上用于骨固定、修复和组织工程是理想的,因为它们在骨愈合后不需要通过手术去除。然而,由未改性的HA制备PLA/HA复合材料通常会由于PLA和HA之间的弱界面而导致机械强度降低。在本研究中,开发了一种磷酸钙/膦酸盐杂化壳,以在HA颗粒上引入更多的活性羟基。然后,通过非离子型表面羟基成功地将PLA接枝到HA上。热重分析表明,聚乳酸在HA上的接枝量可达7%,比文献结果高出约50%。PLA接枝的HA与未接枝的HA表现出明显不同的pH依赖性ζ-电位和粒径分布。通过膦酸偶联剂与表面引发聚合的结合,PLA可以通过共价键直接与HA连接,从而显著提高PLA/HA复合材料中的界面相互作用。由PLA接枝的HA制备的PLA/HA复合材料的直径拉伸强度是由未改性的HA制备的复合材料的两倍以上。此外,改进后的复合材料的抗拉强度比单独的PLA高23%。通过改变额外的变量,这种方法有可能生产出具有改进机械性能的生物可吸收复合材料,这些复合材料在天然骨骼的范围内,并且可以广泛应用于承重区域的骨固定和修复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent.

Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent.

Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent.

Improve the Strength of PLA/HA Composite Through the Use of Surface Initiated Polymerization and Phosphonic Acid Coupling Agent.

Bioresorbable composite made from degradable polymers, e.g., polylactide (PLA), and bioactive calcium phosphates, e.g., hydroxyapatite (HA), are clinically desirable for bone fixation, repair and tissue engineering because they do not need to be removed by surgery after the bone heals. However, preparation of PLA/HA composite from non-modified HA usually results in mechanical strength reductions due to a weak interface between PLA and HA. In this study, a calcium-phosphate/phosphonate hybrid shell was developed to introduce a greater amount of reactive hydroxyl groups onto the HA particles. Then, PLA was successfully grafted on HA by surface-initiated polymerization through the non-ionic surface hydroxyl groups. Thermogravimetric analysis indiated that the amount of grafted PLA on HA can be up to 7 %, which is about 50 % greater than that from the literature. PLA grafted HA shows significantly different pH dependent ζ-potential and particle size profiles from those of uncoated HA. By combining the phosphonic acid coupling agent and surface initiated polymerization, PLA could directly link to HA through covalent bond so that the interfacial interaction in the PLA/HA composite can be significantly improved. The diametral tensile strength of PLA/HA composite prepared from PLA-grafted HA was found to be over twice that of the composite prepared from the non-modified HA. Moreover, the tensile strength of the improved composite was 23 % higher than that of PLA alone. By varying additional variables, this approach has the potential to produce bioresorbable composites with improved mechanical properties that are in the range of natural bones, and can have wide applications for bone fixation and repair in load-bearing areas.

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来源期刊
自引率
33.30%
发文量
10
期刊介绍: The Journal of Research of the National Institute of Standards and Technology is the flagship publication of the National Institute of Standards and Technology. It has been published under various titles and forms since 1904, with its roots as Scientific Papers issued as the Bulletin of the Bureau of Standards. In 1928, the Scientific Papers were combined with Technologic Papers, which reported results of investigations of material and methods of testing. This new publication was titled the Bureau of Standards Journal of Research. The Journal of Research of NIST reports NIST research and development in metrology and related fields of physical science, engineering, applied mathematics, statistics, biotechnology, information technology.
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