Botond Szucs, Mate Petrekanits, Monika Fekete, Janos T Varga
{"title":"使用近红外光谱对慢性阻塞性肺病患者为期 4 周的康复计划进行评估。","authors":"Botond Szucs, Mate Petrekanits, Monika Fekete, Janos T Varga","doi":"10.1556/2060.2021.00185","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Near-infrared spectroscopy (NIRS) technology can evaluate muscle metabolism and oxygenation. NIRS-based oximeters can measure skeletal muscle oxygen delivery and utilization during static and dynamic work non-invasively. Our goal was to assess the value and usability of NIRS technology in chronic obstructive pulmonary disease (COPD) rehabilitation program.</p><p><strong>Methods: </strong>Forty patients with COPD participated in a 4-week inpatient rehabilitation program that included breathing exercises and personalized cycle/treadmill training adjusted to the functional capacity, physical activity and comorbidities of the patients. A NIRS muscle oxygen monitor was used to measure tissue oxygenation and hemoglobin levels. Total hemoglobin index, average muscle oxygenation, minimal and maximal muscle oxygenation were recorded before and after the rehabilitation program.</p><p><strong>Results: </strong>Rehabilitation resulted improvement in 6 min walking distance (6MWD:335.3 ± 110. vs. 398.3 ± 126.2 m; P < 0.01), maximal inspiratory pressure (MIP: 57.7 ± 22.7 vs. 63.6 ± 18.0 cmH2O; P < 0.01), chest wall expansion (CWE: 2.84 ± 1.26 vs, 4.00 ± 1.76 cm; P < 0.01), breath hold time (BHT: 25.8 ± 10.6 vs. 29.2 ± 11.6 s; P < 0.01) and grip strength (GS: 24.9 ± 11.9 vs. 27.0 ± 11.4 kg; P < 0.01). Quality of life improvement was monitored by COPD Assessment Test (CAT: 17.00 ± 8.49 vs. 11.89 ± 7.3, P < 0.05). Total hemoglobin index (tHb: 12.8 ± 1.3% vs. 12.8 ± 1.4), average muscle oxygenation (SmO2: 67.5 ± 14.4% vs. 65.2 ± 20.4%) showed a tendency for improvement. Maximal muscle oxygenation decreased (SmO2 max: 98.0 ± 20.5% vs. 90.1 ± 14.3%; P < 0.01). Minimal muscle oxygenation increased (SmO2 min: 42.6 ± 12.6% vs. 54.8 ± 14.3%; P < 0.01).</p><p><strong>Conclusions: </strong>NIRS results showed that muscle oxygenation and microcirculation can be described as a high-risk factor in COPD patients. The 4-week rehabilitation improves functional parameters, quality of life and tissue oxygenation levels in COPD patients.</p>","PeriodicalId":20058,"journal":{"name":"Physiology international","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The use of near-infrared spectroscopy for the evaluation of a 4-week rehabilitation program in patients with COPD.\",\"authors\":\"Botond Szucs, Mate Petrekanits, Monika Fekete, Janos T Varga\",\"doi\":\"10.1556/2060.2021.00185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Near-infrared spectroscopy (NIRS) technology can evaluate muscle metabolism and oxygenation. NIRS-based oximeters can measure skeletal muscle oxygen delivery and utilization during static and dynamic work non-invasively. Our goal was to assess the value and usability of NIRS technology in chronic obstructive pulmonary disease (COPD) rehabilitation program.</p><p><strong>Methods: </strong>Forty patients with COPD participated in a 4-week inpatient rehabilitation program that included breathing exercises and personalized cycle/treadmill training adjusted to the functional capacity, physical activity and comorbidities of the patients. A NIRS muscle oxygen monitor was used to measure tissue oxygenation and hemoglobin levels. Total hemoglobin index, average muscle oxygenation, minimal and maximal muscle oxygenation were recorded before and after the rehabilitation program.</p><p><strong>Results: </strong>Rehabilitation resulted improvement in 6 min walking distance (6MWD:335.3 ± 110. vs. 398.3 ± 126.2 m; P < 0.01), maximal inspiratory pressure (MIP: 57.7 ± 22.7 vs. 63.6 ± 18.0 cmH2O; P < 0.01), chest wall expansion (CWE: 2.84 ± 1.26 vs, 4.00 ± 1.76 cm; P < 0.01), breath hold time (BHT: 25.8 ± 10.6 vs. 29.2 ± 11.6 s; P < 0.01) and grip strength (GS: 24.9 ± 11.9 vs. 27.0 ± 11.4 kg; P < 0.01). Quality of life improvement was monitored by COPD Assessment Test (CAT: 17.00 ± 8.49 vs. 11.89 ± 7.3, P < 0.05). Total hemoglobin index (tHb: 12.8 ± 1.3% vs. 12.8 ± 1.4), average muscle oxygenation (SmO2: 67.5 ± 14.4% vs. 65.2 ± 20.4%) showed a tendency for improvement. Maximal muscle oxygenation decreased (SmO2 max: 98.0 ± 20.5% vs. 90.1 ± 14.3%; P < 0.01). 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引用次数: 0
摘要
背景:近红外光谱(NIRS)技术可以评估肌肉的新陈代谢和氧饱和度。基于近红外光谱技术的血氧仪可以无创测量骨骼肌在静态和动态工作时的氧气输送和利用情况。我们的目标是评估 NIRS 技术在慢性阻塞性肺病(COPD)康复计划中的价值和可用性:40名慢性阻塞性肺病(COPD)患者参加了为期4周的住院康复计划,该计划包括呼吸练习和根据患者的功能能力、体力活动和合并症调整的个性化循环/跑步机训练。使用近红外肌肉氧监测仪测量组织氧合和血红蛋白水平。记录康复计划前后的总血红蛋白指数、平均肌肉含氧量、最小和最大肌肉含氧量:结果:康复训练改善了 6 分钟步行距离(6MWD:335.3 ± 110.vs. 398.3 ± 126.2 m;P < 0.01)、最大吸气压力(MIP:57.7 ± 22.7 vs. 63.6 ± 18.0 cmH2O;P < 0.01)、胸壁扩张(CWE:2.84 ± 1.26 vs. 4.00 ± 1.76 cm;P < 0.01)、屏气时间(BHT:25.8 ± 10.6 vs. 29.2 ± 11.6 s;P < 0.01)和握力(GS:24.9 ± 11.9 vs. 27.0 ± 11.4 kg;P < 0.01)。慢性阻塞性肺病评估测试(CAT:17.00 ± 8.49 vs. 11.89 ± 7.3,P < 0.05)监测了生活质量的改善情况。总血红蛋白指数(tHb:12.8 ± 1.3% vs. 12.8 ± 1.4)、平均肌肉氧合率(SmO2:67.5 ± 14.4% vs. 65.2 ± 20.4%)呈改善趋势。最大肌肉含氧量下降(最大 SmO2:98.0 ± 20.5% vs. 90.1 ± 14.3%;P < 0.01)。结论:近红外光谱结果表明,肌肉氧饱和度增加(SmO2 min:42.6 ± 12.6% vs. 54.8 ± 14.3%;P < 0.01):NIRS结果显示,肌肉氧合和微循环可被视为慢性阻塞性肺病患者的高危因素。为期四周的康复治疗可改善慢性阻塞性肺病患者的功能参数、生活质量和组织氧合水平。
The use of near-infrared spectroscopy for the evaluation of a 4-week rehabilitation program in patients with COPD.
Background: Near-infrared spectroscopy (NIRS) technology can evaluate muscle metabolism and oxygenation. NIRS-based oximeters can measure skeletal muscle oxygen delivery and utilization during static and dynamic work non-invasively. Our goal was to assess the value and usability of NIRS technology in chronic obstructive pulmonary disease (COPD) rehabilitation program.
Methods: Forty patients with COPD participated in a 4-week inpatient rehabilitation program that included breathing exercises and personalized cycle/treadmill training adjusted to the functional capacity, physical activity and comorbidities of the patients. A NIRS muscle oxygen monitor was used to measure tissue oxygenation and hemoglobin levels. Total hemoglobin index, average muscle oxygenation, minimal and maximal muscle oxygenation were recorded before and after the rehabilitation program.
Results: Rehabilitation resulted improvement in 6 min walking distance (6MWD:335.3 ± 110. vs. 398.3 ± 126.2 m; P < 0.01), maximal inspiratory pressure (MIP: 57.7 ± 22.7 vs. 63.6 ± 18.0 cmH2O; P < 0.01), chest wall expansion (CWE: 2.84 ± 1.26 vs, 4.00 ± 1.76 cm; P < 0.01), breath hold time (BHT: 25.8 ± 10.6 vs. 29.2 ± 11.6 s; P < 0.01) and grip strength (GS: 24.9 ± 11.9 vs. 27.0 ± 11.4 kg; P < 0.01). Quality of life improvement was monitored by COPD Assessment Test (CAT: 17.00 ± 8.49 vs. 11.89 ± 7.3, P < 0.05). Total hemoglobin index (tHb: 12.8 ± 1.3% vs. 12.8 ± 1.4), average muscle oxygenation (SmO2: 67.5 ± 14.4% vs. 65.2 ± 20.4%) showed a tendency for improvement. Maximal muscle oxygenation decreased (SmO2 max: 98.0 ± 20.5% vs. 90.1 ± 14.3%; P < 0.01). Minimal muscle oxygenation increased (SmO2 min: 42.6 ± 12.6% vs. 54.8 ± 14.3%; P < 0.01).
Conclusions: NIRS results showed that muscle oxygenation and microcirculation can be described as a high-risk factor in COPD patients. The 4-week rehabilitation improves functional parameters, quality of life and tissue oxygenation levels in COPD patients.
期刊介绍:
The journal provides a forum for important new research papers written by eminent scientists on experimental medical sciences. Papers reporting on both original work and review articles in the fields of basic and clinical physiology, pathophysiology (from the subcellular organization level up to the oranizmic one), as well as related disciplines, including history of physiological sciences, are accepted.