富亮氨酸重复序列和免疫球蛋白样结构域1缺乏影响海马树突复杂性并损害认知功能

IF 2.7 4区 医学 Q2 DEVELOPMENTAL BIOLOGY
Francisco Javier Hita, Pedro Bekinschtein, Fernanda Ledda, Gustavo Paratcha
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引用次数: 0

摘要

富亮氨酸重复(LRR)跨膜蛋白与神经发育和认知障碍直接相关。我们之前已经证明LRR跨膜蛋白,富含亮氨酸的重复序列和免疫球蛋白样结构域1 (Lrig1),是海马锥体神经元树突复杂性和社会行为的生理调节因子。在这项研究中,我们进行了一系列的行为测试来评估Lrig1突变小鼠的空间记忆和认知能力。认知评估显示了识别和空间记忆的缺陷,通过新物体识别和物体定位测试进行评估。此外,我们发现lrig1缺陷小鼠在空间模式分离任务中相似而非不同位置的加工中存在特异性损伤,这与齿状回双皮质素阳性的未成熟颗粒细胞的树突生长和分支增强有关。总之,这些发现表明Lrig1在控制海马的形态和功能可塑性方面起着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Leucine-rich repeats and immunoglobulin-like domains 1 deficiency affects hippocampal dendrite complexity and impairs cognitive function

Leucine-rich repeat (LRR) transmembrane proteins have been directly linked to neurodevelopmental and cognitive disorders. We have previously shown that the LRR transmembrane protein, leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1), is a physiological regulator of dendrite complexity of hippocampal pyramidal neurons and social behavior. In this study, we performed a battery of behavioral tests to evaluate spatial memory and cognitive capabilities in Lrig1 mutant mice. The cognitive assessment demonstrated deficits in recognition and spatial memory, evaluated by novel object recognition and object location tests. Moreover, we found that Lrig1-deficient mice present specific impairments in the processing of similar but not dissimilar locations in a spatial pattern separation task, which was correlated with an enhanced dendritic growth and branching of Doublecortin-positive immature granule cells of the dentate gyrus. Altogether, these findings indicate that Lrig1 plays an essential role in controlling morphological and functional plasticity in the hippocampus.

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来源期刊
Developmental Neurobiology
Developmental Neurobiology 生物-发育生物学
CiteScore
6.50
自引率
0.00%
发文量
45
审稿时长
4-8 weeks
期刊介绍: Developmental Neurobiology (previously the Journal of Neurobiology ) publishes original research articles on development, regeneration, repair and plasticity of the nervous system and on the ontogeny of behavior. High quality contributions in these areas are solicited, with an emphasis on experimental as opposed to purely descriptive work. The Journal also will consider manuscripts reporting novel approaches and techniques for the study of the development of the nervous system as well as occasional special issues on topics of significant current interest. We welcome suggestions on possible topics from our readers.
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