聚磷腈聚合物:用于再生工程和治疗药物输送的下一代生物材料。

IF 1.5 4区 工程技术 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC
Kenneth S Ogueri, Kennedy S Ogueri, Harry R Allcock, Cato T Laurencin
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引用次数: 0

摘要

在过去的二十年中,由于生物医学技术的不断进步,对再生工程和药物输送等几种生物医学应用中的新生物材料的需求有所增加。可降解高分子生物材料作为支架材料和药物装置继续发挥着重要的作用。聚磷腈平台是一个广泛关注的主题,因为它为获得具有优异结构和性能可调性以及高功能多样性的多功能聚合物材料提供了一条途径。大分子取代使得不同的有机基团和药物分子可以很容易地附着在聚磷腈骨架上,从而开发出种类繁多的材料。这些材料比传统的生物材料更具生物相容性,可与其他临床相关的聚合物混合以获得新材料,并具有接近中性降解产物的独特侵蚀。因此,聚磷腈代表了下一代生物材料。本文综述了聚磷腈的合成设计、结构-性能关系及其在再生工程和给药领域的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery.

The demand for new biomaterials in several biomedical applications, such as regenerative engineering and drug delivery, has increased over the past two decades due to emerging technological advances in biomedicine. Degradable polymeric biomaterials continue to play a significant role as scaffolding materials and drug devices. Polyphosphazene platform is a subject of broad interest, as it presents an avenue for attaining versatile polymeric materials with excellent structure and property tunability, and high functional diversity. Macromolecular substitution enables the facile attachment of different organic groups and drug molecules to the polyphosphazene backbone for the development of a broad class of materials. These materials are more biocompatible than traditional biomaterials, mixable with other clinically relevant polymers to obtain new materials and exhibit unique erosion with near-neutral degradation products. Hence, polyphosphazene represents the next generation of biomaterials. In this review, the authors systematically discuss the synthetic design, structure-property relationships, and the promising potentials of polyphosphazenes in regenerative engineering and drug delivery.

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来源期刊
CiteScore
2.70
自引率
0.00%
发文量
146
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