{"title":"无梗五加叶片中豆烷型皂苷及其对胰脂肪酶的抑制活性","authors":"Kazuma Yoshizumi, Kaoru Hirano, Hidehiro Ando, Yasuaki Hirai, Yoshiteru Ida, Tomoko Tsuji, Tamotsu Tanaka, Kiyoshi Satouchi, Junji Terao","doi":"10.1021/jf052047f","DOIUrl":null,"url":null,"abstract":"<p >Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novel saponin, 3,4-<i>seco</i>-4(23),20(29)-lupadiene-3,28-dioic acid 28-<i>O</i>-α-<span>l</span>-rhamnopyranosyl (1→4)-β-<span>d</span>-glucopyranosyl (1→6)-β-<span>d</span>-glucopyranoside, referred to as sessiloside, were isolated from a hot water extract of <i>Acanthopanax sessiliflorus</i> leaves. All of these saponins were lupane-type triterpene triglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract, respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibility of application of the lupane-type saponins from <i>A. sessiliflorus</i> leaves to the treatment of obesity is discussed. </p><p >Keywords: Lipase inhibitor; <i>Acanthopanax sessiliflorus</i>; lupane-type saponin; chiisanoside; sessiloside; obesity </p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"54 2","pages":"335–341"},"PeriodicalIF":6.2000,"publicationDate":"2005-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1021/jf052047f","citationCount":"99","resultStr":"{\"title\":\"Lupane-Type Saponins from Leaves of Acanthopanax sessiliflorus and Their Inhibitory Activity on Pancreatic Lipase\",\"authors\":\"Kazuma Yoshizumi, Kaoru Hirano, Hidehiro Ando, Yasuaki Hirai, Yoshiteru Ida, Tomoko Tsuji, Tamotsu Tanaka, Kiyoshi Satouchi, Junji Terao\",\"doi\":\"10.1021/jf052047f\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novel saponin, 3,4-<i>seco</i>-4(23),20(29)-lupadiene-3,28-dioic acid 28-<i>O</i>-α-<span>l</span>-rhamnopyranosyl (1→4)-β-<span>d</span>-glucopyranosyl (1→6)-β-<span>d</span>-glucopyranoside, referred to as sessiloside, were isolated from a hot water extract of <i>Acanthopanax sessiliflorus</i> leaves. All of these saponins were lupane-type triterpene triglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract, respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibility of application of the lupane-type saponins from <i>A. sessiliflorus</i> leaves to the treatment of obesity is discussed. </p><p >Keywords: Lipase inhibitor; <i>Acanthopanax sessiliflorus</i>; lupane-type saponin; chiisanoside; sessiloside; obesity </p>\",\"PeriodicalId\":41,\"journal\":{\"name\":\"Journal of Agricultural and Food Chemistry\",\"volume\":\"54 2\",\"pages\":\"335–341\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2005-12-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1021/jf052047f\",\"citationCount\":\"99\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Agricultural and Food Chemistry\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/jf052047f\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Agricultural and Food Chemistry","FirstCategoryId":"97","ListUrlMain":"https://pubs.acs.org/doi/10.1021/jf052047f","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
Lupane-Type Saponins from Leaves of Acanthopanax sessiliflorus and Their Inhibitory Activity on Pancreatic Lipase
Three known saponins, chiisanoside, 11-deoxyisochiisanoside, and isochiisanoside, and one novel saponin, 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid 28-O-α-l-rhamnopyranosyl (1→4)-β-d-glucopyranosyl (1→6)-β-d-glucopyranoside, referred to as sessiloside, were isolated from a hot water extract of Acanthopanax sessiliflorus leaves. All of these saponins were lupane-type triterpene triglycosides, and their concentrations were 4.1, 1.0, 0.5, and 0.4% (w/w) of the total extract, respectively. Sessiloside and chiisanoside inhibited pancreatic lipase activity in vitro, and addition of the saponin-rich fraction to a high-fat diet suppressed the body weight gain of mice. The possibility of application of the lupane-type saponins from A. sessiliflorus leaves to the treatment of obesity is discussed.
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The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.
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