30 岁突触修饰的 BCM 理论：理论与实验的互动

IF 28.7 1区医学 Q1 NEUROSCIENCES

Nature Reviews Neuroscience Pub Date : 2012-10-19 DOI:10.1038/nrn3353

Leon N Cooper, Mark F. Bear

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引用次数: 309

摘要

突触可塑性的 BCM 理论至今已有 30 年历史。在这篇《视角》文章中，库珀和熊讨论了这一理论如何推进了我们对突触可塑性、学习和记忆的理解，并强调了这一理论在神经科学研究中的重要作用。自埃利-比年斯托克（Elie Bienenstock）、莱昂-库珀（Leon Cooper）和保罗-芒罗（Paul Munro）的 "神经元选择性发展理论：视觉皮层的方向特异性和双目相互作用"（即突触可塑性的 BCM 理论）发表以来，30 年过去了。该理论指导实验人员发现了突触可塑性的一些基本特性，并提供了一种数学结构，将学习和记忆存储的分子机制与系统级后果联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The BCM theory of synapse modification at 30: interaction of theory with experiment

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The BCM theory of synapse modification at 30: interaction of theory with experiment

The BCM theory of synaptic plasticity is now 30 years old. In this Perspective article, Cooper and Bear discuss how this theory has advanced our understanding of synaptic plasticity, learning and memory and highlight the important role that theory can have in neuroscience research. Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro''s ''Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex'', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.

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来源期刊

Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.