催产素通过中枢杏仁核的不同输出选择性地控制恐惧反应

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2011-07-01 DOI:10.1126/science.1201043

Daniele Viviani, Alexandre Charlet, Erwin van den Burg, Camille Robinet, Nicolas Hurni, Marios Abatis, Fulvio Magara, Ron Stoop

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引用次数: 334

摘要

杏仁核中枢（CeA）向下丘脑和脑干核团的投射可调节恐惧的行为和生理表现，但恐惧反应的这些不同方面是否可分别受到 CeA 的调节尚不清楚。我们结合体外电生理记录和体内相关行为和生理参数监测，对调节恐惧相关冻结或心血管反应的核团的CeA投射进行了荧光逆行追踪。CeA投射来自不同的神经元群，它们具有不同的电生理特征和对催产素的不同反应特性。在体内，催产素可减少恐惧条件反射大鼠的冻结反应，但不影响心血管反应。因此，神经肽能信号可通过不同的神经元回路调节CeA输出，从而单独引导恐惧反应的各个方面。

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Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate neuronal populations with different electrophysiological characteristics and different response properties to oxytocin. In vivo, oxytocin decreased freezing responses in fear-conditioned rats without affecting the cardiovascular response. Thus, neuropeptidergic signaling can modulate the CeA outputs through separate neuronal circuits and thereby individually steer the various aspects of the fear response.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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