可注射的磷灰石形成预混水泥的性能。

IF 1.5 4区 工程技术
Yashushi Shimada, Laurence C Chow, Shozo Takagi, Junji Tagami
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引用次数: 0

摘要

以前的研究报告称,预混合磷酸钙水门汀(CPC)在包装中很稳定,暴露于水性环境后会形成羟基磷灰石(HA)。这些水门汀的凝固时间超过 60 分钟,时间过长,无法用于某些临床应用。本研究调查了快速固化 HA 形成预混合 CPC 的特性,这些 CPC 最初由两种独立的预混合浆料组成:(1) 磨细(中值尺寸为 1.0 μm)的无水磷酸氢钙 (DCPA) 与 NaH(2)PO(4) 水溶液(1.5 摩尔/升或 3.0 摩尔/升)混合。5 mol/L 或 3.0 mol/L 浓度的无水磷酸二钙(DCPA)与 NaH(2)PO(4) 水溶液(浓度为 1.5 mol/L 或 3.0 mol/L)混合;(2) 磷酸四钙由中值尺寸为 5 μm (TTCP5) 和 17 μm (TTCP17)的两种不同尺寸分布的颗粒组合而成,并与甘油混合。使用装有静态混合器的双管注射器将等体积的浆料 1 和 2 注入样品模具。混合浆料的 Ca/P 摩尔比约为 1.5。对水泥的凝结时间(吉尔莫针)、直径拉伸强度(DTS)和相组成(粉末 X 射线衍射,XRD)进行了表征。凝结时间为(4.3 ± 0.6 至 68 ± 3)分钟(平均值 ± sd;n = 3),1 d 和 7 d DTS 值为(0.89 ± 0.08 至 2.44 ± 0.16)兆帕(平均值 ± sd;n = 5)。NaH(2)PO(4) 浓度和 TTCP 粒径分布对凝固时间和 DTS 均有显著影响(p < 0.01)。粉末 XRD 分析表明,1 天试样中存在低结晶度的 HA 和未反应的 DCPA,HA 的形成程度随 TTCP 浆料中 TTCP5 含量的增加而增加。结论:以 DCPA 和 TTCP 为成分可制备凝固时间为 4 至 70 分钟的可注射 HA 成型预混合 CPC。与传统的粉末液体水泥相比,这些预混合 CPC 具有使用方便、硬化时间范围广等优点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Properties of Injectable Apatite-Forming Premixed Cements.

Properties of Injectable Apatite-Forming Premixed Cements.

Properties of Injectable Apatite-Forming Premixed Cements.

Properties of Injectable Apatite-Forming Premixed Cements.

Previous studies reported premixed calcium phosphate cements (CPCs) that were stable in the package and form hydroxyapatite (HA) as the product after exposure to an aqueous environment. These cements had setting times of greater than 60 min, which are too long to be useful for some clinical applications. The present study investigated properties of fast-setting HA-forming premixed CPCs that initially consisted of two separate premixed pastes: (1) finely ground (1.0 μm in median size) dicalcium phosphate anhydrous (DCPA) mixed with an aqueous NaH(2)PO(4) solution, 1.5 mol/L or 3.0 mol/L in concentration, and (2) tetracalcium phosphate consisting of combinations of particles of two different size distributions, 5 μm (TTCP5) and 17 μm (TTCP17) in median size, mixed with glycerin. Equal volume of Pastes 1 and 2 were injected with the use of atwo-barrel syringe fitted with a static mixer into sample molds. The molar Ca/P ratio of combined paste was approximately 1.5. Cements were characterized in terms of setting time (Gilmore needle), diametral tensile strength (DTS), and phase composition (powder x-ray diffraction, XRD). Setting times were found to range from (4.3 ± 0.6 to 68 ± 3) min (mean ± sd; n = 3), and 1-d and 7-d DTS values were from (0.89 ± 0.08 to 2.44 ± 0.16) MPa (mean ± sd; n = 5). Both the NaH(2)PO(4) concentration and TTCP particle size distribution had significant (p < 0.01) effects on setting time and DTS. Powder XRD analysis showed that low crystallinity HA and unreacted DCPA were present in the 1-day specimens, and the extent of HA formation increased with increasing amount of TTCP5 in the TTCP paste. CONCLUSION: Injectable HA-forming premixed CPCs with setting times from 4 to 70 min can be prepared by using DCPA and TTCP as the ingredients. Compared to the conventional powder liquid cements, these premixed CPCs have the advantages of being easy to use and having a range of hardening times.

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来源期刊
自引率
33.30%
发文量
10
期刊介绍: The Journal of Research of the National Institute of Standards and Technology is the flagship publication of the National Institute of Standards and Technology. It has been published under various titles and forms since 1904, with its roots as Scientific Papers issued as the Bulletin of the Bureau of Standards. In 1928, the Scientific Papers were combined with Technologic Papers, which reported results of investigations of material and methods of testing. This new publication was titled the Bureau of Standards Journal of Research. The Journal of Research of NIST reports NIST research and development in metrology and related fields of physical science, engineering, applied mathematics, statistics, biotechnology, information technology.
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