形成氟磷灰石的磷酸钙胶结物的体内外特性

IF 1.5 4区 工程技术
Shozo Takagi, Stan Frukhtbeyn, Laurence C Chow, Akiyoshi Sugawara, Kenji Fujikawa, Hidehiro Ogata, Makoto Hayashi, Binnai Ogiso
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引用次数: 14

摘要

本研究首次报道了氟磷灰石(FA)形成的磷酸钙胶结物(CPCs)的体内外性能。实验水泥含有(0 ~ 3.1)质量%的F,对应于FA的含量约为(0 ~ 87)质量%。随着FA含量的增加,磷灰石水泥产品的结晶度大大提高。大鼠皮下注射后,体内吸收率随FA含量的增加而显著降低。FA含量最高的水泥不被软组织吸收,使其成为已知的第一个具有生物相容性和生物惰性的CPC。这些生物惰性cpc对于需要缓慢或不吸收植入物以达到预期临床效果的应用可能是有用的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements.

In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements.

In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements.

In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements.

This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

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来源期刊
自引率
33.30%
发文量
10
期刊介绍: The Journal of Research of the National Institute of Standards and Technology is the flagship publication of the National Institute of Standards and Technology. It has been published under various titles and forms since 1904, with its roots as Scientific Papers issued as the Bulletin of the Bureau of Standards. In 1928, the Scientific Papers were combined with Technologic Papers, which reported results of investigations of material and methods of testing. This new publication was titled the Bureau of Standards Journal of Research. The Journal of Research of NIST reports NIST research and development in metrology and related fields of physical science, engineering, applied mathematics, statistics, biotechnology, information technology.
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