[抗cd20单克隆抗体治疗多发性硬化症患者继发性低γ -球蛋白血症的管理指南]。

IF 1.2 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Acta medica portuguesa Pub Date : 2026-10-01 Epub Date: 2026-07-15 DOI:10.20344/amp.24365

André Aires Fernandes, Ana Lídia Neves, Daniela Ferro, Mafalda Seabra, Ricardo Soares Dos Reis, Teresa Mendonça, Cândida Abreu, Joana Guimarães, Pedro Abreu

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引用次数: 0

摘要

低γ -球蛋白血症是用抗cd20单克隆抗体治疗多发性硬化症患者常见的实验室并发症，它可能与感染风险增加有关。该指南由奥约地方大学Saúde suniade Local de脑脊液研究和研究部制定，提出了一种评估和管理这种疾病的结构化方法。它概述了治疗前和治疗期间降低感染风险的策略，以及在适当情况下启动免疫球蛋白替代治疗的适应症。目的是通过促进安全、个性化和以患者为中心的干预来支持临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

[Guidelines for the Management of Secondary Hypogammaglobulinemia in Multiple Sclerosis Patients on Anti-CD20 Monoclonal Antibody Therapy].

Hypogammaglobulinemia is a common laboratory complication in patients with multiple sclerosis treated with anti-CD20 monoclonal antibodies, and it may be associated with an increased risk of infections. This guideline, developed by the Cerebrospinal Fluid Study and Research Unit of Unidade Local de Saúde São João, proposes a structured approach for the assessment and management of this condition. It outlines strategies for infection risk mitigation both before and during therapy, as well as the indications for initiating immunoglobulin replacement therapy when appropriate. The aim is to support clinical decision-making by promoting a safe, individualized, and patient-centered intervention.

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来源期刊

Acta medica portuguesa MEDICINE, GENERAL & INTERNAL-

CiteScore

1.90

自引率

16.70%

发文量

256

审稿时长

6-12 weeks

期刊介绍： The aim of Acta Médica Portuguesa is to publish original research and review articles in biomedical areas of the highest standard, covering several domains of medical knowledge, with the purpose to help doctors improve medical care. In order to accomplish these aims, Acta Médica Portuguesa publishes original articles, review articles, case reports and editorials, among others, with a focus on clinical, scientific, social, political and economic factors affecting health. Acta Médica Portuguesa will be happy to consider manuscripts for publication from authors anywhere in the world.