Jung Min Kim, Yun Seo Park, Jeong Sang Yi, Byeong-Min Lee, Hyun-Ju Kim, Kihyun Kim, Kwang-Hee Son, Sang Hee Shim, Yeo Joon Yoon
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Isolation and Identification of Multiple Nematicides Produced by Streptomyces sp. AN091965
Streptomyces are vital
sources of
bioactive metabolites. From Streptomyces sp. AN091965 culture extracts, seven secondary metabolites were
identified. Five showed nematicidal activity: spectinabilin (1), its unprecedented derivative (Z,E,E,Z)-spectinabilin (2), homoaureothin (3),
undecylprodigiosin (4) and metacycloprodigiosin (5), while two spectinabilin derivatives, SNF 4435C (6) and SNF 4435D (7) were immunosuppressive.
Subsequent biological assays demonstrated that compound 2 exhibited remarkable nematicidal activity, surpassing the commercial
agent fosthiazate and showing comparable efficacy to abamectin. This
study not only reports a novel nematicide but also demonstrates the
strain’s unique capacity to produce multiple nematicides, serving
as a promising host strain for biopesticide production.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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