EQ-5D在血液学癌症中的有效性、可靠性和反应性：测量特性的系统回顾。

IF 6.2 2区医学 Q1 ECONOMICS

Value in Health Pub Date : 2026-09-01 Epub Date: 2026-04-13 DOI:10.1016/j.jval.2026.03.2239

Aleksandra Dudzisz MSc, Grzegorz W. Basak MD, Emilian Snarski MD, Dominik Golicki MD

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引用次数: 0

摘要

目的：本研究旨在对已发表的关于成年血液学癌症患者EQ-5D （EQ-5D- 3l和EQ-5D- 5l）测量特性的证据进行系统回顾。方法：利用MEDLINE、EMBASE和Web of Science（截至2025年10月）进行综合文献检索。本文收录了有关EQ-5D测量特性（包括构念效度、重测信度或反应性）的原创研究的英文全文。涉及EQ-5D实验版本的研究被排除在外。质量评估采用COSMIN偏倚风险检查表，数据综合采用COSMIN方法。结果：共有来自31个国家的16项研究纳入了EQ-5D测量特性的996项单独测试（96%符合结果）。EQ- 5d - 5l指标、EQ- 5d - 5l维度、EQ- 5d - 3l指标、EQ- 5d - 3l维度和EQ VAS具有足够的建构效度，确定性较高。关于重测信度的证据仅限于EQ- 5d - 5l指数和EQ VAS，具有中等和低的确定性，并表明测量性能的总体评级足够。通过104项试验（EQ- 5d - 5l指数100项，EQ- 5d - 3l指数2项，EQ VAS 2项）评估反应性。大多数测试显示了预期的方向变化（97%;101/104）。结论：本系统综述综述了EQ-5D作为血液学癌症HRQoL测量指标的测量特性。现有证据表明，EQ-5D-3L和EQ-5D-5L具有足够的结构效度，可用于评估该患者群体的HRQoL。可靠性和响应性的证据仍然有限，需要进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Validity, Reliability, and Responsiveness of the EQ-5D in Hematological Cancers: A Systematic Review of Measurement Properties

Objectives

This study aimed to conduct a systematic review of the published evidence regarding the measurement properties of the EuroQoL 5-Dimension (EQ-5D) (3 level [EQ-5D-3L] and 5 level [EQ-5D-5L]) in adult patients with hematological cancers.

Methods

A comprehensive literature search was carried out utilizing the MEDLINE, EMBASE, and Web of Science (up to October 2025). Full-text English articles focusing on original research concerning the measurement properties of the EQ-5D, including construct validity, test-retest reliability, or responsiveness, were included. Studies involving experimental versions of the EQ-5D were excluded. The quality assessment utilized the COSMIN Risk of Bias checklist, and data synthesis followed the COSMIN methodology.

Results

A total of 16 studies from 31 countries, presenting 996 individual tests (96% met results) of the EQ-5D measurement properties were included. Sufficient construct validity for EQ-5D-5L index, EQ-5D-5L dimensions, EQ-5D-3L index, EQ-5D-3L dimensions, and EQ visual analog scale (VAS) was supported by high certainty. Evidence regarding test-retest reliability was limited to EQ-5D-5L index and EQ VAS, had moderate and low certainty, and indicated sufficient overall rating of measurement properties. Responsiveness was assessed in 104 tests (100 for EQ-5D-5L index, 2 for EQ-5D-3L index, 2 for EQ VAS). Most tests demonstrated the expected directional change (97%; 101/104).

Conclusion

This systematic review provides an overview of the measurement properties of the EQ-5D as a health-related quality-of-life measure in hematological cancers. The available evidence suggests that both EQ-5D-3L and EQ-5D-5L have sufficient construct validity and may be used to assess health-related quality of life in this patient population. Evidence for reliability and responsiveness remains limited and warrants further investigation.

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来源期刊

Value in Health 医学-卫生保健

CiteScore

6.90

自引率

6.70%

发文量

3064

审稿时长

3-8 weeks

期刊介绍： Value in Health contains original research articles for pharmacoeconomics, health economics, and outcomes research (clinical, economic, and patient-reported outcomes/preference-based research), as well as conceptual and health policy articles that provide valuable information for health care decision-makers as well as the research community. As the official journal of ISPOR, Value in Health provides a forum for researchers, as well as health care decision-makers to translate outcomes research into health care decisions.