Exaggerating the risks of vaccination is a dangerous health threat.

Vaccine hesitancy and opposition lacking empirical support represent significant threats to public health, particularly when amplified by public health officials. This commentary provides evidence-based refutation of such anti-vaccine arguments, including (i) the robust epidemiological data demonstrating vaccine efficacy in reducing disease incidence, mortality, and transmission; (ii) the comprehensive safety surveillance systems (VAERS, VSD, CISA) that monitor adverse events and consistently demonstrate favorable risk-benefit profiles; (iii) the biological mechanisms underlying both vaccine-induced immunity and rare adverse events; and (iv) the distinction between temporal association and causation in adverse event reporting. Thus it can be deduced that flawed logic and falsifications have been used to misrepresent the risks of vaccination. This endangers the lives and well-being of people who are susceptible to the diseases that vaccines can effectively prevent.