前庭受累的双侧急性内耳（迷路）损伤小鼠模型揭示了前庭代偿的功能、行为和组织学相关性。

IF 3.2 4区医学 Q3 NEUROSCIENCES

Neuroscience Research Pub Date : 2025-12-01 Epub Date: 2025-11-08 DOI:10.1016/j.neures.2025.104982

Jingyi Xie , Xiaotong Zhang , Shengli Li , Zichen Chen , Xujia Zhang , Jinyi Tian , Yulu Yan , Yongqi Pan , Ke Shi , Jianbin Sun , Teru Kamogashira , Ying Gao

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引用次数: 0

摘要

双侧前庭功能障碍破坏平衡和空间定向，但损伤和补偿机制仍不完全明确。我们建立了双侧急性内耳（迷路）损伤并前庭受损伤的小鼠模型，通过连续切开圆形和椭圆形窗口，并在术后1-28天内评估听觉脑干反应（ABR）、前庭感觉诱发电位（VsEP）、行为和组织学。阈值升高和行为障碍在第3天达到顶峰，毛细胞退化在早期最为突出，第28天部分形态恢复。这些发现描绘了急性损伤阶段和早期稳定，为研究前庭修复和功能恢复提供了平台。

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A mouse model of bilateral acute inner-ear (labyrinthine) injury with vestibular involvement reveals functional, behavioral, and histological correlates of vestibular compensation

Bilateral vestibular dysfunction disrupts balance and spatial orientation, yet mechanisms of injury and compensation remain incompletely defined. We established a mouse model of bilateral acute inner-ear (labyrinthine) injury with vestibular involvement by sequentially incising the round and oval windows, and evaluate auditory brainstem responses (ABR), vestibular sensory-evoked potentials (VsEP), behavior, and histology across postoperative days 1–28. Threshold elevations and behavioral impairment peaked on day 3, with hair-cell degeneration most prominent early and partial morphological recovery by day 28. These findings delineate the acute injury phase and early stabilization, providing a platform to study vestibular repair and functional recovery.

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来源期刊

Neuroscience Research 医学-神经科学

CiteScore

5.60

自引率

3.40%

发文量

136

审稿时长

28 days

期刊介绍： The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.