青少年掉队：哮喘随机对照试验中代表性不足。

IF 2.3 4区医学 Q2 PEDIATRICS

BMJ Paediatrics Open Pub Date : 2025-10-22 DOI:10.1136/bmjpo-2025-003905

Amy G Nuttall, Catherine McNamara, William Bedson, Emma Wilkinson, Ian Sinha, Paul McNamara

{"title":"青少年掉队：哮喘随机对照试验中代表性不足。","authors":"Amy G Nuttall, Catherine McNamara, William Bedson, Emma Wilkinson, Ian Sinha, Paul McNamara","doi":"10.1136/bmjpo-2025-003905","DOIUrl":null,"url":null,"abstract":"To guide adolescent asthma management, evidence of treatment efficacy and safety is needed. We searched multiple databases for randomised control trials (RCTs) of pharmaceutical asthma therapies recruiting adolescents and adults between 2015 and 2023 to ascertain the proportion of adolescents recruited. 81 RCTs were identified, with 49 (60.5%) not reporting the number/proportion of adolescents recruited. Where the proportion of adolescents was reported, this ranged between 1% and 49% (median 6.1%). Only 7 (8.6%) trials reported adolescent subgroup data. In published asthma RCTs, it is frequently unclear whether adolescents have been recruited, with the proportion low when reported. Consideration is needed when using this data to manage adolescent asthma.CRD42021233497.","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"9 1","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adolescents left behind: underrepresentation in asthma randomised controlled trials.\",\"authors\":\"Amy G Nuttall, Catherine McNamara, William Bedson, Emma Wilkinson, Ian Sinha, Paul McNamara\",\"doi\":\"10.1136/bmjpo-2025-003905\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"To guide adolescent asthma management, evidence of treatment efficacy and safety is needed. We searched multiple databases for randomised control trials (RCTs) of pharmaceutical asthma therapies recruiting adolescents and adults between 2015 and 2023 to ascertain the proportion of adolescents recruited. 81 RCTs were identified, with 49 (60.5%) not reporting the number/proportion of adolescents recruited. Where the proportion of adolescents was reported, this ranged between 1% and 49% (median 6.1%). Only 7 (8.6%) trials reported adolescent subgroup data. In published asthma RCTs, it is frequently unclear whether adolescents have been recruited, with the proportion low when reported. Consideration is needed when using this data to manage adolescent asthma.CRD42021233497.\",\"PeriodicalId\":9069,\"journal\":{\"name\":\"BMJ Paediatrics Open\",\"volume\":\"9 1\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMJ Paediatrics Open\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/bmjpo-2025-003905\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Paediatrics Open","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/bmjpo-2025-003905","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

摘要

为了指导青少年哮喘管理，需要治疗有效性和安全性的证据。我们检索了多个数据库，检索了2015年至2023年间招募青少年和成人的药物哮喘治疗的随机对照试验（rct），以确定招募的青少年比例。确定了81项随机对照试验，其中49项（60.5%）未报告招募青少年的数量/比例。在报告青少年比例的地方，这一比例在1%至49%之间（中位数为6.1%）。只有7项（8.6%）试验报告了青少年亚组数据。在已发表的哮喘随机对照试验中，通常不清楚是否招募了青少年，报告的比例很低。当使用这些数据来管理青少年哮喘时，需要考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Adolescents left behind: underrepresentation in asthma randomised controlled trials.

To guide adolescent asthma management, evidence of treatment efficacy and safety is needed. We searched multiple databases for randomised control trials (RCTs) of pharmaceutical asthma therapies recruiting adolescents and adults between 2015 and 2023 to ascertain the proportion of adolescents recruited. 81 RCTs were identified, with 49 (60.5%) not reporting the number/proportion of adolescents recruited. Where the proportion of adolescents was reported, this ranged between 1% and 49% (median 6.1%). Only 7 (8.6%) trials reported adolescent subgroup data. In published asthma RCTs, it is frequently unclear whether adolescents have been recruited, with the proportion low when reported. Consideration is needed when using this data to manage adolescent asthma.CRD42021233497.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

BMJ Paediatrics Open Medicine-Pediatrics, Perinatology and Child Health

CiteScore

4.10

自引率

3.80%

发文量

124