亲吻，退缩，逃跑

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-10-16 DOI:10.1126/science.aec0091

Katharina Lichter

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引用次数: 0

摘要

突触囊泡是储存和运输神经递质的微小膜球。它们通过与突触前膜融合，将神经递质释放到突触间隙，从而实现大脑神经元之间的交流，这一过程被称为胞吐作用。这种机制是突触传递不可或缺的。然而，囊泡融合的精确模式仍未得到解决，关于突触囊泡是完全崩溃还是只是短暂融合，以及它们的循环速度有多快，存在着相互竞争的理论。解决这些差异是具有挑战性的，因为这些过程在纳米尺度上发生在几毫秒内。在这期杂志的第258页，Tao等人(1)报道了使用时间分辨低温电子断层扫描原位观察突触囊泡动态的方法。他们提出了一个统一的模型，在这个模型中，囊泡在缩小和完整分离之前，通过一个稳定的孔短暂地融合和释放神经递质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Kiss, shrink, run

Synaptic vesicles are tiny membrane spheres that store and transport neurotransmitters. They enable communication between neurons in the brain by fusing with the presynaptic membrane to release neurotransmitters into the synaptic cleft, a process known as exocytosis. This mechanism is indispensable for synaptic transmission. Yet the precise mode of vesicle fusion remains unresolved, and there are competing theories about whether synaptic vesicles fully collapse or fuse only transiently and about how rapidly they are recycled. Resolving these discrepancies is challenging because these processes occur within milliseconds at nanometer dimensions. On page 258 of this issue, Tao et al. (1) report using time-resolved cryo–electron tomography to visualize synaptic vesicle dynamics in situ. They propose a unified model in which vesicles transiently fuse and release neurotransmitters through a stable pore before downsizing and detaching intact.

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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