{"title":"张树柑黄酮的提取、表征及抗衰老评价","authors":"Jiapan Gan, Jiayan Xie, Xin Xu, Jiahao Ai, Sisi He, Jiafen Zou, Qiang Yu, Hongli Jin, Yanfang Liu, Xinmiao Liang","doi":"10.1039/d5fo02218e","DOIUrl":null,"url":null,"abstract":"<p><p>ZhangTouHong (ZTH), a highly valuable edible-medicinal resource rich in bioactive flavonoids, has little been studied in terms of its chemical composition and biological activities. In this work, a process was developed for the preparation of flavonoid multi-components (FMCs) from ZTH, which showed high efficiency and specificity and a 4.62-fold increased total flavonoid content. Based on UPLC-Q-TOF-MS/MS and molecular networks, the FMCs in ZTH were identified for the first time, with a total of 48 flavonoid compounds, including 3 potential new compounds. Moreover, the results of anti-aging activity tests demonstrated that the FMCs have excellent antioxidant activity and anti-aging capacity, extending the lifespan of nematodes by 21.65% and the survival time of oxidative stress in nematodes by 35.71%. In summary, this study established an efficient and scalable process for the preparation of bioactive flavonoid components and, for the first time, verified the anti-aging effect of ZTH FMCs, providing the scientific basis for the deep development and industrial application of this characteristic citrus resource.</p>","PeriodicalId":77,"journal":{"name":"Food & Function","volume":" ","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Extraction, characterization, and anti-aging evaluation of flavonoids from <i>Citrus reticulata</i> 'Zhangshuensis'.\",\"authors\":\"Jiapan Gan, Jiayan Xie, Xin Xu, Jiahao Ai, Sisi He, Jiafen Zou, Qiang Yu, Hongli Jin, Yanfang Liu, Xinmiao Liang\",\"doi\":\"10.1039/d5fo02218e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ZhangTouHong (ZTH), a highly valuable edible-medicinal resource rich in bioactive flavonoids, has little been studied in terms of its chemical composition and biological activities. In this work, a process was developed for the preparation of flavonoid multi-components (FMCs) from ZTH, which showed high efficiency and specificity and a 4.62-fold increased total flavonoid content. Based on UPLC-Q-TOF-MS/MS and molecular networks, the FMCs in ZTH were identified for the first time, with a total of 48 flavonoid compounds, including 3 potential new compounds. Moreover, the results of anti-aging activity tests demonstrated that the FMCs have excellent antioxidant activity and anti-aging capacity, extending the lifespan of nematodes by 21.65% and the survival time of oxidative stress in nematodes by 35.71%. In summary, this study established an efficient and scalable process for the preparation of bioactive flavonoid components and, for the first time, verified the anti-aging effect of ZTH FMCs, providing the scientific basis for the deep development and industrial application of this characteristic citrus resource.</p>\",\"PeriodicalId\":77,\"journal\":{\"name\":\"Food & Function\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food & Function\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1039/d5fo02218e\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food & Function","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1039/d5fo02218e","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Extraction, characterization, and anti-aging evaluation of flavonoids from Citrus reticulata 'Zhangshuensis'.
ZhangTouHong (ZTH), a highly valuable edible-medicinal resource rich in bioactive flavonoids, has little been studied in terms of its chemical composition and biological activities. In this work, a process was developed for the preparation of flavonoid multi-components (FMCs) from ZTH, which showed high efficiency and specificity and a 4.62-fold increased total flavonoid content. Based on UPLC-Q-TOF-MS/MS and molecular networks, the FMCs in ZTH were identified for the first time, with a total of 48 flavonoid compounds, including 3 potential new compounds. Moreover, the results of anti-aging activity tests demonstrated that the FMCs have excellent antioxidant activity and anti-aging capacity, extending the lifespan of nematodes by 21.65% and the survival time of oxidative stress in nematodes by 35.71%. In summary, this study established an efficient and scalable process for the preparation of bioactive flavonoid components and, for the first time, verified the anti-aging effect of ZTH FMCs, providing the scientific basis for the deep development and industrial application of this characteristic citrus resource.
期刊介绍：
Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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