利用QTOF-LCMS和计算分析方法检测俄罗斯马叶松的代谢物,探索绿色纳米技术和抗植物病原体的抗真菌药物

IF 5.2 2区 农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY
Reham M. Aldahasi, Sahar S. Alghamdi, Nouf Albulushi, Hanin Alhuraibi, Rasha Saad Suliman, Arwa Alsubait, Amirah S. Alahmari, Afrah E. Mohammed
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引用次数: 0

摘要

目的探索马叶松作为绿色合成抗真菌纳米材料的可持续来源。为了应对日益增加的植物病原真菌和环境问题,本文重点研究了利用木犀草提取物制备锰纳米颗粒(MnONPs)、氮掺杂碳点(N-CDs)及其纳米复合材料(MnO NPs@N-CDs)。方法采用紫外-可见分光光度法、FTIR、DLS、TEM、EDX等方法对合成的纳米材料进行表征。评价了其对菌核菌核菌、木叶镰刀菌和venenatum镰刀菌的抑菌效果。此外,通过LC-QTOF-MS鉴定生物活性代谢物,并通过计算工具评估其抗真菌活性、药代动力学特征和毒性水平。结果木犀草提取物制备的纳米材料可显著抑制真菌的生长,显示其作为植物病害防治的环保解决方案的潜力。大多数代谢物表现出良好的安全性,预测的心脏毒性和致突变性最小,表明它们有望成为安全的杀菌剂。Equisetiformis提供了有效的抗真菌活性和低毒的化合物,为可持续的植物病害管理提供了一种有前途的、环保的化学杀菌剂替代品。为了扩大其在农业中的应用,有必要进行进一步的研究。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolite detection via QTOF-LCMS and computational analysis on Russelia equisetiformis exploring green nanotechnology and antifungal against phytopathogens

Objectives

This study explores Russelia equisetiformis as a sustainable source for the green synthesis of antifungal nanomaterials. In response to increasing phytopathogenic fungi and environmental issues, it focuses on the fabrication of manganese nanoparticles (MnONPs), nitrogen-doped carbon dots (N-CDs), and their nanocomposite (MnO NPs@N-CDs) using R. equisetiformis extract.

Methods

The synthesized nanomaterials were characterized by UV–Vis spectrophotometry, FTIR, DLS, TEM, and EDX to confirm nanoparticle formation. Their antifungal effectiveness was evaluated against Sclerotinia sclerotiorum, Fusarium equiseti, and Fusarium venenatum. Additionally, bioactive metabolites were identified via LC–QTOF-MS, and their antifungal activity, pharmacokinetic profiles, and toxicity levels were assessed through computational tools.

Results

Nanomaterials produced from R. equisetiformis extract significantly reduced fungal growth, highlighting their potential as eco-friendly solutions for plant disease control. Most metabolites exhibited favorable safety profiles with minimal predicted cardiotoxicity and mutagenicity, indicating their promise as safe fungicides.

Conclusion

R. equisetiformis provides compounds with effective antifungal activity and low toxicity, offering a promising, environmentally friendly alternative to conventional chemical fungicides for sustainable plant disease management. Further research is essential to expand their application in agriculture.

Graphical Abstract

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来源期刊
Chemical and Biological Technologies in Agriculture
Chemical and Biological Technologies in Agriculture Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
6.80
自引率
3.00%
发文量
83
审稿时长
15 weeks
期刊介绍: Chemical and Biological Technologies in Agriculture is an international, interdisciplinary, peer-reviewed forum for the advancement and application to all fields of agriculture of modern chemical, biochemical and molecular technologies. The scope of this journal includes chemical and biochemical processes aimed to increase sustainable agricultural and food production, the evaluation of quality and origin of raw primary products and their transformation into foods and chemicals, as well as environmental monitoring and remediation. Of special interest are the effects of chemical and biochemical technologies, also at the nano and supramolecular scale, on the relationships between soil, plants, microorganisms and their environment, with the help of modern bioinformatics. Another special focus is the use of modern bioorganic and biological chemistry to develop new technologies for plant nutrition and bio-stimulation, advancement of biorefineries from biomasses, safe and traceable food products, carbon storage in soil and plants and restoration of contaminated soils to agriculture. This journal presents the first opportunity to bring together researchers from a wide number of disciplines within the agricultural chemical and biological sciences, from both industry and academia. The principle aim of Chemical and Biological Technologies in Agriculture is to allow the exchange of the most advanced chemical and biochemical knowledge to develop technologies which address one of the most pressing challenges of our times - sustaining a growing world population. Chemical and Biological Technologies in Agriculture publishes original research articles, short letters and invited reviews. Articles from scientists in industry, academia as well as private research institutes, non-governmental and environmental organizations are encouraged.
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