Reham M. Aldahasi, Sahar S. Alghamdi, Nouf Albulushi, Hanin Alhuraibi, Rasha Saad Suliman, Arwa Alsubait, Amirah S. Alahmari, Afrah E. Mohammed
{"title":"利用QTOF-LCMS和计算分析方法检测俄罗斯马叶松的代谢物,探索绿色纳米技术和抗植物病原体的抗真菌药物","authors":"Reham M. Aldahasi, Sahar S. Alghamdi, Nouf Albulushi, Hanin Alhuraibi, Rasha Saad Suliman, Arwa Alsubait, Amirah S. Alahmari, Afrah E. Mohammed","doi":"10.1186/s40538-025-00850-7","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>This study explores <i>Russelia equisetiformis</i> as a sustainable source for the green synthesis of antifungal nanomaterials. In response to increasing phytopathogenic fungi and environmental issues, it focuses on the fabrication of manganese nanoparticles (MnONPs), nitrogen-doped carbon dots (<i>N</i>-CDs), and their nanocomposite (MnO NPs@N-CDs) using <i>R. equisetiformis</i> extract.</p><h3>Methods</h3><p>The synthesized nanomaterials were characterized by UV–Vis spectrophotometry, FTIR, DLS, TEM, and EDX to confirm nanoparticle formation. Their antifungal effectiveness was evaluated against <i>Sclerotinia sclerotiorum, Fusarium equiseti</i>, and <i>Fusarium venenatum</i>. Additionally, bioactive metabolites were identified via LC–QTOF-MS, and their antifungal activity, pharmacokinetic profiles, and toxicity levels were assessed through computational tools.</p><h3>Results</h3><p>Nanomaterials produced from <i>R. equisetiformis</i> extract significantly reduced fungal growth, highlighting their potential as eco-friendly solutions for plant disease control. Most metabolites exhibited favorable safety profiles with minimal predicted cardiotoxicity and mutagenicity, indicating their promise as safe fungicides.</p><h3>Conclusion</h3><p><i>R. equisetiformis</i> provides compounds with effective antifungal activity and low toxicity, offering a promising, environmentally friendly alternative to conventional chemical fungicides for sustainable plant disease management. Further research is essential to expand their application in agriculture.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":512,"journal":{"name":"Chemical and Biological Technologies in Agriculture","volume":"12 1","pages":""},"PeriodicalIF":5.2000,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chembioagro.springeropen.com/counter/pdf/10.1186/s40538-025-00850-7","citationCount":"0","resultStr":"{\"title\":\"Metabolite detection via QTOF-LCMS and computational analysis on Russelia equisetiformis exploring green nanotechnology and antifungal against phytopathogens\",\"authors\":\"Reham M. Aldahasi, Sahar S. Alghamdi, Nouf Albulushi, Hanin Alhuraibi, Rasha Saad Suliman, Arwa Alsubait, Amirah S. Alahmari, Afrah E. Mohammed\",\"doi\":\"10.1186/s40538-025-00850-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>This study explores <i>Russelia equisetiformis</i> as a sustainable source for the green synthesis of antifungal nanomaterials. In response to increasing phytopathogenic fungi and environmental issues, it focuses on the fabrication of manganese nanoparticles (MnONPs), nitrogen-doped carbon dots (<i>N</i>-CDs), and their nanocomposite (MnO NPs@N-CDs) using <i>R. equisetiformis</i> extract.</p><h3>Methods</h3><p>The synthesized nanomaterials were characterized by UV–Vis spectrophotometry, FTIR, DLS, TEM, and EDX to confirm nanoparticle formation. Their antifungal effectiveness was evaluated against <i>Sclerotinia sclerotiorum, Fusarium equiseti</i>, and <i>Fusarium venenatum</i>. Additionally, bioactive metabolites were identified via LC–QTOF-MS, and their antifungal activity, pharmacokinetic profiles, and toxicity levels were assessed through computational tools.</p><h3>Results</h3><p>Nanomaterials produced from <i>R. equisetiformis</i> extract significantly reduced fungal growth, highlighting their potential as eco-friendly solutions for plant disease control. Most metabolites exhibited favorable safety profiles with minimal predicted cardiotoxicity and mutagenicity, indicating their promise as safe fungicides.</p><h3>Conclusion</h3><p><i>R. equisetiformis</i> provides compounds with effective antifungal activity and low toxicity, offering a promising, environmentally friendly alternative to conventional chemical fungicides for sustainable plant disease management. Further research is essential to expand their application in agriculture.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":512,\"journal\":{\"name\":\"Chemical and Biological Technologies in Agriculture\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2025-10-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://chembioagro.springeropen.com/counter/pdf/10.1186/s40538-025-00850-7\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical and Biological Technologies in Agriculture\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://link.springer.com/article/10.1186/s40538-025-00850-7\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical and Biological Technologies in Agriculture","FirstCategoryId":"97","ListUrlMain":"https://link.springer.com/article/10.1186/s40538-025-00850-7","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
Metabolite detection via QTOF-LCMS and computational analysis on Russelia equisetiformis exploring green nanotechnology and antifungal against phytopathogens
Objectives
This study explores Russelia equisetiformis as a sustainable source for the green synthesis of antifungal nanomaterials. In response to increasing phytopathogenic fungi and environmental issues, it focuses on the fabrication of manganese nanoparticles (MnONPs), nitrogen-doped carbon dots (N-CDs), and their nanocomposite (MnO NPs@N-CDs) using R. equisetiformis extract.
Methods
The synthesized nanomaterials were characterized by UV–Vis spectrophotometry, FTIR, DLS, TEM, and EDX to confirm nanoparticle formation. Their antifungal effectiveness was evaluated against Sclerotinia sclerotiorum, Fusarium equiseti, and Fusarium venenatum. Additionally, bioactive metabolites were identified via LC–QTOF-MS, and their antifungal activity, pharmacokinetic profiles, and toxicity levels were assessed through computational tools.
Results
Nanomaterials produced from R. equisetiformis extract significantly reduced fungal growth, highlighting their potential as eco-friendly solutions for plant disease control. Most metabolites exhibited favorable safety profiles with minimal predicted cardiotoxicity and mutagenicity, indicating their promise as safe fungicides.
Conclusion
R. equisetiformis provides compounds with effective antifungal activity and low toxicity, offering a promising, environmentally friendly alternative to conventional chemical fungicides for sustainable plant disease management. Further research is essential to expand their application in agriculture.
期刊介绍:
Chemical and Biological Technologies in Agriculture is an international, interdisciplinary, peer-reviewed forum for the advancement and application to all fields of agriculture of modern chemical, biochemical and molecular technologies. The scope of this journal includes chemical and biochemical processes aimed to increase sustainable agricultural and food production, the evaluation of quality and origin of raw primary products and their transformation into foods and chemicals, as well as environmental monitoring and remediation. Of special interest are the effects of chemical and biochemical technologies, also at the nano and supramolecular scale, on the relationships between soil, plants, microorganisms and their environment, with the help of modern bioinformatics. Another special focus is the use of modern bioorganic and biological chemistry to develop new technologies for plant nutrition and bio-stimulation, advancement of biorefineries from biomasses, safe and traceable food products, carbon storage in soil and plants and restoration of contaminated soils to agriculture.
This journal presents the first opportunity to bring together researchers from a wide number of disciplines within the agricultural chemical and biological sciences, from both industry and academia. The principle aim of Chemical and Biological Technologies in Agriculture is to allow the exchange of the most advanced chemical and biochemical knowledge to develop technologies which address one of the most pressing challenges of our times - sustaining a growing world population.
Chemical and Biological Technologies in Agriculture publishes original research articles, short letters and invited reviews. Articles from scientists in industry, academia as well as private research institutes, non-governmental and environmental organizations are encouraged.