{"title":"成瘾的躯体心理治疗的神经生理和治疗效果:探索性交叉成瘾分析的主要行为焦点。","authors":"Christopher Lomas","doi":"10.1080/10550887.2025.2560404","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Behavioral addictions exhibit convergent dysregulation of meso-striatal reward, cortico-limbic stress, and executive-control circuits. Top-down interventions such as CBT demonstrate moderate, often transient effects, leaving autonomic dysregulation insufficiently targeted. Somatic and body-oriented psychotherapies (SBPs) may remediate these deficits <i>via</i> bottom-up interoceptive and autonomic mechanisms, but quantitative synthesis is lacking.</p><p><strong>Methods: </strong>Nine randomized controlled trials (RCTs) (total <i>N</i> = 573) of yoga, mindfulness, or somatic interventions for gambling, gaming, or compulsive sexual behavior were systematically reviewed. Hedges' g was pooled using random-effects meta-analysis (DerSimonian-Laird, Hartung-Knapp intervals). Risk-of-bias was evaluated with RoB-2; sensitivity analyses included leave-one-out models.</p><p><strong>Results: </strong>Pooled effect size indicated a large benefit (g = -2.62, 95% CI [-4.73, -0.51], <i>p</i> = .015), with heterogeneity substantial (<i>I</i><sup>2</sup> = 95.6%). Directionality persisted under sensitivity analyses. No serious adverse events were reported.</p><p><strong>Conclusions: </strong>This review delivers the first quantitative synthesis of SBPs in behavioral addictions, delineating robust short-term symptom reduction alongside preliminary mechanistic signals implicating interoceptive-autonomic and fronto-striatal circuits. A novel phased, biomarker-guided treatment framework is proposed, situating SBPs as adjunctive modulators within integrative addiction care. Future trials should prioritize mechanistic endpoints, longer follow-up, and dismantling designs to isolate active components.</p>","PeriodicalId":47493,"journal":{"name":"Journal of Addictive Diseases","volume":" ","pages":"1-21"},"PeriodicalIF":1.1000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neurophysiological and therapeutic efficacy of somatic psychotherapies in addiction: primary behavioral focus with exploratory cross-addiction analyses.\",\"authors\":\"Christopher Lomas\",\"doi\":\"10.1080/10550887.2025.2560404\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Behavioral addictions exhibit convergent dysregulation of meso-striatal reward, cortico-limbic stress, and executive-control circuits. Top-down interventions such as CBT demonstrate moderate, often transient effects, leaving autonomic dysregulation insufficiently targeted. Somatic and body-oriented psychotherapies (SBPs) may remediate these deficits <i>via</i> bottom-up interoceptive and autonomic mechanisms, but quantitative synthesis is lacking.</p><p><strong>Methods: </strong>Nine randomized controlled trials (RCTs) (total <i>N</i> = 573) of yoga, mindfulness, or somatic interventions for gambling, gaming, or compulsive sexual behavior were systematically reviewed. Hedges' g was pooled using random-effects meta-analysis (DerSimonian-Laird, Hartung-Knapp intervals). Risk-of-bias was evaluated with RoB-2; sensitivity analyses included leave-one-out models.</p><p><strong>Results: </strong>Pooled effect size indicated a large benefit (g = -2.62, 95% CI [-4.73, -0.51], <i>p</i> = .015), with heterogeneity substantial (<i>I</i><sup>2</sup> = 95.6%). Directionality persisted under sensitivity analyses. No serious adverse events were reported.</p><p><strong>Conclusions: </strong>This review delivers the first quantitative synthesis of SBPs in behavioral addictions, delineating robust short-term symptom reduction alongside preliminary mechanistic signals implicating interoceptive-autonomic and fronto-striatal circuits. A novel phased, biomarker-guided treatment framework is proposed, situating SBPs as adjunctive modulators within integrative addiction care. Future trials should prioritize mechanistic endpoints, longer follow-up, and dismantling designs to isolate active components.</p>\",\"PeriodicalId\":47493,\"journal\":{\"name\":\"Journal of Addictive Diseases\",\"volume\":\" \",\"pages\":\"1-21\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-10-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Addictive Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10550887.2025.2560404\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"SUBSTANCE ABUSE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Addictive Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10550887.2025.2560404","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
引用次数: 0
摘要
背景:行为成瘾表现出中纹状体奖励、皮质边缘应激和执行控制回路的趋同失调。自上而下的干预,如CBT,显示出适度的,通常是短暂的效果,使自主神经失调没有充分的针对性。躯体和身体导向的心理疗法(sbp)可以通过自下而上的内感受和自主机制来弥补这些缺陷,但缺乏定量的综合。方法:系统回顾了9项随机对照试验(rct)(总N = 573),涉及瑜伽、正念或躯体干预对赌博、游戏或强迫性行为的影响。采用随机效应荟萃分析(dersimonan - laird, Hartung-Knapp区间)汇总对冲数据。用rob2评估偏倚风险;敏感性分析包括留一模型。结果:合并效应大小表明获益较大(g = -2.62, 95% CI [-4.73, -0.51], p = 0.015),异质性较大(I2 = 95.6%)。在敏感性分析中,方向性仍然存在。无严重不良事件报告。结论:这篇综述首次对行为成瘾中的sbp进行了定量合成,描述了短期症状的显著减轻以及涉及内感觉-自主神经和额纹状体回路的初步机制信号。提出了一种新的分阶段、生物标志物指导的治疗框架,将sbp定位为综合成瘾治疗中的辅助调节剂。未来的试验应优先考虑机械终点、更长时间的随访和分离活性成分的拆解设计。
Neurophysiological and therapeutic efficacy of somatic psychotherapies in addiction: primary behavioral focus with exploratory cross-addiction analyses.
Background: Behavioral addictions exhibit convergent dysregulation of meso-striatal reward, cortico-limbic stress, and executive-control circuits. Top-down interventions such as CBT demonstrate moderate, often transient effects, leaving autonomic dysregulation insufficiently targeted. Somatic and body-oriented psychotherapies (SBPs) may remediate these deficits via bottom-up interoceptive and autonomic mechanisms, but quantitative synthesis is lacking.
Methods: Nine randomized controlled trials (RCTs) (total N = 573) of yoga, mindfulness, or somatic interventions for gambling, gaming, or compulsive sexual behavior were systematically reviewed. Hedges' g was pooled using random-effects meta-analysis (DerSimonian-Laird, Hartung-Knapp intervals). Risk-of-bias was evaluated with RoB-2; sensitivity analyses included leave-one-out models.
Results: Pooled effect size indicated a large benefit (g = -2.62, 95% CI [-4.73, -0.51], p = .015), with heterogeneity substantial (I2 = 95.6%). Directionality persisted under sensitivity analyses. No serious adverse events were reported.
Conclusions: This review delivers the first quantitative synthesis of SBPs in behavioral addictions, delineating robust short-term symptom reduction alongside preliminary mechanistic signals implicating interoceptive-autonomic and fronto-striatal circuits. A novel phased, biomarker-guided treatment framework is proposed, situating SBPs as adjunctive modulators within integrative addiction care. Future trials should prioritize mechanistic endpoints, longer follow-up, and dismantling designs to isolate active components.
期刊介绍:
The Journal of Addictive Diseases is an essential, comprehensive resource covering the full range of addictions for today"s addiction professional. This in-depth, practical journal helps you stay on top of the vital issues and the clinical skills necessary to ensure effective practice. The latest research, treatments, and public policy issues in addiction medicine are presented in a fully integrated, multi-specialty perspective. Top researchers and respected leaders in addiction issues share their knowledge and insights to keep you up-to-date on the most important research and practical applications.